Manning Lab
The Manning lab is defining the molecular connections between nutrient signaling and metabolic networks under both physiological and pathological states. Lab researchers are particularly focused on the role of the PI3K-mTOR signaling network in the control of cellular and systemic metabolism and its impact on the insulin response, type-2 diabetes, cancer, neurological disorders, and aging.
665 Huntington Ave
Building 2, Rm. 127
Boston, MA 02115
Meet the Team
Brendan D. Manning
Brendan D. Manning is the Chair of and a Professor in the Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health and the Department of Cell Biology at Harvard Medical School, and a Faculty Member of the Dana-Farber/Harvard Cancer Center. Dr. Manning received his B.S. from the University of Massachusetts, Amherst, and his Ph.D. from Yale University. During his time as a postdoctoral fellow in the laboratory of Lewis Cantley at Harvard Medical School, he discovered that the tuberous sclerosis complex (TSC) tumor suppressors serve as the molecular connection between the PI3K and mTOR pathways, thereby linking a signaling pathway activated in the majority of human cancers to a nutrient-sensing pathway that controls cell growth and metabolism.
In 2004, he joined the faculty of the then newly established Department of Genetics and Complex Diseases at Harvard (renamed Molecular Metabolism in 2019) to continue research at the interface of cell signaling and metabolism. Research in the Manning laboratory is particularly focused on the regulation and function of the PI3K – mTOR signaling network in physiology and disease. Dr. Manning was an inaugural recipient of the National Cancer Institute’s Outstanding Investigator Award.
Please contact Tom Kelleher to set up a meeting with Dr. Manning – tkelleher@hsph.harvard.edu
Research Associates
Research Associate:
2023 –
Postdoctoral Fellow:
2017 – 2023
Education:
Ph.D., 2016, University of Sophia Antipolis, Nice, France
Research Interest:
Yann is interested in defining the in vivo role of PI3K-mTORC1 signaling in mammalian growth and metabolism.
Postdoctoral Fellows
Postdoctoral Fellow:
2020 –
Education:
B.S. Cell and Molecular Biology, 2013, University of Montpellier II
M.S, Bio-Medical Research, 2015, University of Montpellier II: Control of the cell fate -Cancer
Ph.D., 2019, University of Montpellier
Research Interest:
Madi is interested in how signaling processes can control metabolic pathways and particularly how cancer cells can regulate their metabolism through these molecular mechanisms.
Doctoral Student:
2019 – 2023
Education:
Ph.D., 2023, Harvard T.H. Chan School of Public Health
B.S., 2015, University of Pittsburgh
Research Interest:
Krystle is interested in understanding how the mTOR signaling network is regulated by nutrient availability and dietary conditions, and how this impacts cellular and systemic metabolism in healthy organisms, as well as in metabolic disease and aging. I am also interested in dissecting the tissue-specific roles of mTOR signaling.
Postdoctoral Fellow:
2024 –
Education:
Ph.D., Paris Cité University – 2023
M.S., Molecular and Cellular Biology, Sorbonne University, Paris – 2019
B.S., Life Sciences, Sorbonne University, Paris – 2017
Research Interests:
Khaled is interested in understanding how the different branches of the lipid metabolism are coordinated in health and disease, with a focus on cancer and senescence.
Doctoral Students
Doctoral Student:
2020 –
Education:
M.S., 2020, University of Illinois at Urbana-Champaign
B.S., 2018, Tulane University
Research Interest:
Samuel focuses on discovering the mechanisms underlying how skeletal muscle balances protein and carbohydrate metabolism to contribute to overall metabolic homeostasis. Specifically, he is investigating how the tuberous sclerosis complex (TSC) subunit 2 (TSC2) acts as a switchboard to balance upstream signals such as insulin into outputs such as protein synthesis and glucose uptake and storage. By studying this pathway in skeletal muscle, we may uncover treatments for disorders in skeletal muscle function as well as broader metabolic disorders.
Faculty Assistant
Manning Lab Administrative Coordinator:
2020 –
Education:
B.S. Music and Theatrical Performance, 2008, Muhlenberg College
M.F.A. in Theater Education from Emerson College
Objective Focus:
Faculty Assistant to Dr. Manning and coordinator for the Department of Molecular Metabolism