Department of Molecular Metabolism
Researching the complex interplay between the major factors underlying metabolic health and disease, including diet, age, environment, and genetics, for the prevention and treatment of widespread chronic diseases.
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News
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Aging December 4, 2024
Can humans live longer? Maybe.
William Mair—whose lab focuses on the biology of the aging process—was a guest on a Nov. 29 podcast focused on the limits of human longevity.
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Aging October 21, 2024
Life expectancy may be reaching upper limits—for now
William Mair, professor of molecular metabolism at Harvard T.H. Chan School of Public Health, shares what researchers know about the biology of aging, the importance of improving health span, and the need to take moonshots.
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May 10, 2024
Youth in Public Health symposium 2024
In April 2024, under the guidance of Dr. Liming Liang, the Harvard University Office for Equity, Diversity, Inclusion & Belonging (EDIB) and the Interdisciplinary Discussion on Disease and Health, A…
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Aging May 9, 2024
A molecular dive into how cells sense nutrients
Krystle Kalafut, PhD ’24, studies the liver’s response to insulin, revealing potential mechanisms involved in obesity and diabetes.
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May 6, 2024
IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia
Cancer cachexia, a debilitating syndrome characterized by systemic wasting in cancer patients, has long confounded researchers seeking to identify its underlying mechanisms. A recent study published in EMBO Reports sheds…
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February 26, 2024
Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion
In a recent publication in The Journal of Clinical Investigation, Abigael Cheruiyot, PhD, of the Schaffer Lab, led the research that uncovered a translational regulatory circuit within pancreatic beta cells…
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Cancer February 7, 2024
A surprising look at the mechanics of metastasis
Scientists at Harvard T.H. Chan School of Public Health are peering deep inside lymph nodes to learn more about how cancer cells spread—and whether we may someday be able to halt metastasis through dietary modifications.
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November 14, 2023
The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans
Aging is a natural process, yet it can be accelerated or delayed by internal and external factors. In particular, CREB-regulated transcriptional coactivators (CRTCs) have emerged as novel modulators of aging…
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October 5, 2023
Sympathetic tone dictates the impact of lipolysis on FABP4 secretion
In a paper recently published in the Journal of Lipid Research, Kacey Prentice and a group of scientists from Hotamışlıgil Lab at the Sabri Ülker Center demonstrated that secretion of…
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October 5, 2023
Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion
In a paper published in JCI Insight, titled, “Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion”, a team of researchers from the Hotamışlıgil…
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