Department of Molecular Metabolism
Researching the complex interplay between the major factors underlying metabolic health and disease, including diet, age, environment, and genetics, for the prevention and treatment of widespread chronic diseases.
665 Huntington Avenue
Building 2, 1st Floor
News
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May 6, 2024
IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia
Cancer cachexia, a debilitating syndrome characterized by systemic wasting in cancer patients, has long confounded researchers seeking to identify its underlying mechanisms. A recent study published in EMBO Reports sheds…
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February 26, 2024
Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion
In a recent publication in The Journal of Clinical Investigation, Abigael Cheruiyot, PhD, of the Schaffer Lab, led the research that uncovered a translational regulatory circuit within pancreatic beta cells…
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Cancer February 7, 2024
A surprising look at the mechanics of metastasis
Scientists at Harvard T.H. Chan School of Public Health are peering deep inside lymph nodes to learn more about how cancer cells spread—and whether we may someday be able to halt metastasis through dietary modifications.
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November 14, 2023
The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans
Aging is a natural process, yet it can be accelerated or delayed by internal and external factors. In particular, CREB-regulated transcriptional coactivators (CRTCs) have emerged as novel modulators of aging…
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October 5, 2023
Sympathetic tone dictates the impact of lipolysis on FABP4 secretion
In a paper recently published in the Journal of Lipid Research, Kacey Prentice and a group of scientists from Hotamışlıgil Lab at the Sabri Ülker Center demonstrated that secretion of…
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October 5, 2023
Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion
In a paper published in JCI Insight, titled, “Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion”, a team of researchers from the Hotamışlıgil…
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October 5, 2023
Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans
In a recent paper published in PLoS Genetics, Dr. Mair and his team led by Hannah Smith, demonstrated that selectively inhibiting mechanistic target of rapamycin complex 1 (mTORC1) in neurons…
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Chronic Diseases September 14, 2023
Department of Molecular Metabolism celebrates 20th anniversary
Over 100 current and former members of Harvard T.H. Chan School of Public Health’s Department of Molecular Metabolism gathered on September 7 to celebrate the 20th anniversary of the department’s founding, to reflect on the successes of the past two decades, and to look ahead to promising research in the field of metabolism.
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June 30, 2023
Quad Garage Advisory- WAB Promenade Project and Quad Garage Ramp
Department Representatives, Due to the WAB Promenade Project, the Quad garage ramp will be reduced to one lane at all times starting on Thursday, June 15th. The project is expected…
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June 30, 2023
New European Union Shipping/Import Regulations Effective March 1st, 2023
Dear Department Administrators and Associate Directors of Finance: Please share this important shipping information with all shippers in your Harvard Chan Departments. The European Union (EU) is implementing a new…
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