Manning Lab
The Manning lab is defining the molecular connections between nutrient signaling and metabolic networks under both physiological and pathological states. Lab researchers are particularly focused on the role of the PI3K-mTOR signaling network in the control of cellular and systemic metabolism and its impact on the insulin response, type-2 diabetes, cancer, neurological disorders, and aging.
665 Huntington Ave
Building 2, Rm. 127
Boston, MA 02115
Manning Lab Alumni
Postdoctoral Fellow Alumni
Education:
Ph.D., 2016, Charité Berlin (Germany)
M.Sc., 2011, Charité Berlin (Germany)B.Sc., 2009, University of Bremen (Germany) and University of Glasgow (UK)
Research Interest:
Sandra is interested in understanding PI3K-Akt-TSC1/2-mTOR signaling in neurons. She is focused on identifying neurodevelopmental and metabolic defects caused by aberrant signaling of this pathway.
Education:
Ph.D., 2017, Massachusetts Institute of Technology
A.B., 2011, Princeton University
Research Interest:
Aaron is interested in studying the crosstalk between metabolic and signaling pathways. He is particularly interested in understanding how cells regulate their metabolism to enable proliferation in normal and disease states.
Current Position:
Assistant Professor of Pharmacology – Rutgers Robert Wood Johnson Medical School
Education:
Ph.D., 2013, University of Pennsylvania
B.A., 2006, University of Delaware
Current Position:
Medical Manager at SSI Strategy
Education:
Ph.D., 2015, University of Arizona
B.A., 2006, University of Edinburgh (Scotland)
Current Position:
Assistant Professor at Children’s Research Institute at UT Southwestern
Education:
Ph.D., 2012, MRC-PPU, University of Dundee, Scotland, UK
B.S., 2008, Bogazici University, Istanbul, Turkey
Current Position:
Assistant Professor of Biochemistry and Molecular Genetics
Northwestern University Feinberg School of Medicine Department of Biochemistry and Molecular Genetics
Education:
Ph.D., 2010, University of Nice Côte d’Azur (France) Cellular and Molecular Biology
M.S, 2007, University of Nice Côte d’Azur (France) Genetics, Immunity and Development
B.S., 2005, University of Nice Côte d’Azur (France) Life Sciences
Current Position:
Scientist, Navitor Pharmaceuticals
Education:
Ph.D., 2009, Rockefeller University
B.A., 2004, University of Pennsylvania
Research Interests:
Jessica is interested in using mouse models and in vitro methods to elucidate the layers of regulation that govern cellular functions, particularly those relevant to metabolic disease. She is investigating metabolic changes induced by mTOR signaling and is exploring the role of mTOR repression in ameliorating the diabetic phenotype.
Her research is supported, in part, by a fellowship from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.
Current Position:
Senior Scientist, AbbVie
Education:
Ph.D. 2009 – University of Toronto, Canada
M.S. 2000 – Institute of Biophysics of Chinese Academy of Sciences, China
B.S. 1997 – Nankai University, China
Research Interests:
Cancer cells are dramatically different from normal cells in their metabolic functions. Yinan’s research aims at identifying metabolic and stress response pathways that provide the most attractive intervention points for treating cancer. Armed with such knowledge, he is trying to target these pathways by screening chemical compounds in search of new classes of cancer therapeutics.
Current Position:
Research Investigator, Novartis
Education:
Ph.D., 2008, Yale University
Current Position:
Senior Regulatory Scientist, Medical Device/ Account Manager at Voisin Consulting Life Sciences
Education:
Ph.D., 2009, University of Geneva, Switzerland
Current Position:
Compliance Officer at Harvard University, The Wyss Institute for Biologically Inspired Engineering
Education:
PhD University of Erlangen-Nuremberg
MSc The Philipp University of Marburg
B.S. The Philipp University of Marburg
Current Position:
VP of Clinical Development at Infinity Pharmaceuticals
Education:
Ph.D., 2000, University of Birmingham (UK)
Doctoral Student Alumni
Current Position:
Associate Scientist, Servier Pharmaceuticals
Education:
Ph.D., 2022, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 2016, Massachusetts Institute of Technology
Research Interest:
Molly is interested in understanding the dysregulation of the PI3K-mTOR signaling network in cancer and uncovering novel therapeutic strategies.
Current Position:
Life Sciences Consultant at Putnam
Education:
Ph.D., 2022, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.A., 2012, Colorado College
Research Interest:
Sophie is interested in understanding the dysregulation of signaling networks in cancer and translating novel pathway discoveries into therapeutic outcomes.
Current Position:
Postdoctoral Fellow in the Jacks Lab at MIT
Education:
Ph.D., 2021, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 2015, Massachusetts Institute of Technology
Current Position:Associate Scientist at Agios Pharmaceuticals
Education:
Ph.D., 2020, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
M.A., 2013, Nutrition and Metabolism, Boston University School of Medicine
B.S., 2008, Human Physiology, Boston University
Current Position:
Life Sciences Consultant at Putnam Associates
Education:
Ph.D., 2019, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
M.S., 2013, Johns Hopkins Bloomberg School of Public Health
B.S., 2008, University of Rochester
Research Interest:
Erika is interested in examining the molecular mechanisms by which oncogenic signaling pathways alter cellular metabolism.
Current Position:
Postdoctoral Fellow, Miller-Jensen Lab, Yale University and Adjunct Professor at Southern Connecticut State University
Education:
Ph.D., 2017, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 2011, University of Maryland
Current Position:
Manager at Simon-Kucher & Partners
Education:
Ph.D., 2016, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 2010, Massachusetts Institute of Technology, Cambridge, MA
Current Position:
Director at BeiGene
Education:
Ph.D., 2012, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 2008, Princeton University
Current Position:
Pathology Consultant, National University of Singapore
Education:
Ph.D., 2009, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
M.D. National University of Singapore
M.B.B.S National University of Singapore
Research Assistants
Education:
B.S., 2022, University of Michigan
Research Interests:
The role of the PI3K-mTOR signaling pathway in cancer, diabetes, and neurodegenerative diseases to create an avenue for potential therapies.
Current Position:
Research Associate at FL84
Education:
B.A., 2019, Hamilton College, Clinton, New York
Research Interest:
Meghan is interested in the role of the PI3K-mTOR signaling pathway in relation to cancer and the regulation of metabolism. More specifically, how this pathway regulates metabolism to trigger growth and proliferation.
Current Position:
Postdoctoral Fellow in the Jacks Lab at MIT
Education:
B.S., 2016, Cornell University
Current Position:
Horticulture researcher turned agtech enthusiast.
Education:
B.S., 2017, University of Wisconsin, Madison
Research Interests:
Graham’s background is in botanical genetics; specifically Mendelian inheritance, ethylene signaling, and glandular trichrome engineering. Having garnered an understanding of the therapeutic potential of plant-derived compounds, he now aims to investigate biochemical interactions in disease
Current Position:
PhD Student at The Rockefeller University
Education:
B.S., 2015, Northeastern University
Research Interest:
Erika is interested in examining the molecular mechanisms by which oncogenic signaling pathways alter cellular metabolism.
Current Position:
Postdoctoral Fellow, UCSF
Education:
B.S. 2012, Tufts University
Current Position:
Research Scientist at Verndari INC
Education:
M.S., 2011, University of Denver
B.S., 2006, University of California, Davis
Current Position:
Research Scientist, Neuroscience Next Generation Therapeutics at Eli Lilly and Company
Education:
B.S., 2010, University of Massachusetts, Amherst
Current Position:
Orthodontist with Sealy Orthodontics
Education:
Ph.D., 2011, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 1997, Cornell University
Current Position:
Assistant Professor, Johns Hopkins Bloomberg School of Public Health
Education:
PhD, 2016, University of London
MPH, 2009, Harvard T.H. Chan School of Public Health
MS, 2005, Columbia University
Current Position:
Principal Scientist at Bristol Myers Squibb
Education:
PhD, 2013, Yale University, Virology
B.A., 2004, Boston University, Biochemistry and Molecular Biology