Publications

2024

• Kwon, Y.Y., and Hui, S. (2024). IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia. EMBO Rep, 1-18.
• Yuan, B., Inouye, K.E., Hotamisligil, G., and Hui, S. (2024). An Organism-Level Quantitative Flux Model of Mammalian Energy Metabolism. bioRxiv, 2024.2002.2011.579776.
• Stanley, S., Wang, X., Liu, Q., Kwon, Y.Y., Frey, A.M., Hicks, N.D., Vickers, A.J., Hui, S., and Fortune, S.M. (2024). Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure. PLOS Pathogens 20, e1012050.

2023

• Chitraju, C., Fischer, A.W., Ambaw, Y.A., Wang, K., Yuan, B., Hui, S., Walther, T.C., and Farese, R.V., Jr. (2023). Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity. eLife 12, RP88049.
• Ferrer, M., Anthony, T.G., Ayres, J.S., Biffi, G., Brown, J.C., Caan, B.J., Cespedes Feliciano, E.M., Coll, A.P., Dunne, R.F., Goncalves, M.D., McCandlish, D., Mustian, K.M., Hui, S., et al. (2023). Cachexia: A systemic consequence of progressive, unresolved disease. Cell 186, 1824-1845.
• Yao, C.-H., Park, J.S., Kurmi, K., Hu, S.-H., Notarangelo, G., Crowley, J., Jacobson, H., Hui, S., Sharpe, A.H., and Haigis, M.C. (2023). Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis. Molecular Cell 83, 1340-1349.e1347.
• Yook, J.-S., Taxin, Z.H., Yuan, B., Oikawa, S., Auger, C., Mutlu, B., Puigserver, P., Hui, S., and Kajimura, S. (2023). The SLC25A47 locus controls gluconeogenesis and energy expenditure. Proceedings of the National Academy of Sciences 120, e2216810120.

2022

• X. Li, S. Hui, E. T. Mirek, W. O. Jonsson, T. G. Anthony, W. D. Lee, X. Zeng, C. Jang and J. D. Rabinowitz. Circulating metabolite homeostasis achieved through mass action. Nature Metabolism (2022)

2021

• X. Wang, J. Frederick, H. Wang, S. Hui, V. Backman and Z. Ji. Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anticancer drug response. NAR genomics and bioinformatics (2021)
•  T. TeSlaa, C. R. Bartman, C. S. R. Jankowski, Z. Zhao, X. Xu, X. Xing, L. Wang, W. Lu, S. Hui and J. D. Rabinowitz. The source of glycolytic intermediates in mammalian tissues. Cell Metabolism (2021) 

2020

• Y. Wang, S. Hui, F. Wondisford and X. Su. Utilizing tandem mass spectrometry for metabolic flux analysis. Laboratory Investigation (2020)
• S. Hui*#, A. J. Cowan*, X. Zeng, L. Yang, T. TeSlaa, X. Li, C. Bartman, Z. Zhao, C. Jang, L. Wang, W. Lu, J. Rojas, J. Baur and J. D. Rabinowitz#. Quantitative fluxomics of circulating metabolites. Cell Metabolism (2020) [*equal contribution; #corresponding author]

2019

• C. Jang, S. Hui, X. Zeng, A. J. Cowan, L. Wang, L. Chen, R. J. Morscher, J. Reyes, C. Frezza, H. Y. Hwang, A. Imai, Y. Saito, K. Okamoto, C. Vaspoli, L. Kasprenski, G. A. Zsido II, J. H. Gorman III, R. C. Gorman and J. D. Rabinowitz. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metabolism 30, 594-606 (2019)
• M. D. Neinast*, C. Jang*, S. Hui, D. S. Murashige, Q. Chu, R. J. Morscher, L. Zhan, E. White, T. G. Anthony, J. D. Rabinowitz and Z. Arany. Whole-body metabolic fate of branched chain amino acids in health and insulin resistance. Cell Metabolism 29, 417- 429 (2019)

2018

• S. Hui and J. D. Rabinowitz. An unexpected trigger for calorie burning in brown fat. Nature 560, 38-39 (2018)
• L. Liu, X. Su, W. J. Quinn III, S. Hui, K. Krukenberg, D. W. Frederick, P. Redpath, L. Zhan, K. Chellappa, Eileen White, M. Migaud, T. J. Mitchison, J. A. Baur and J. D. Rabinowitz. Quantitative analysis of NAD synthesis-breakdown fluxes. Cell metabolism 27, 1067-1080 (2018)
• C. Jang, S. Hui, W. Lu, A. J. Cowan, R. J. Morscher, G. Lee, W. Liu, G. J. Tesz, M. J. Birnbaum and J. D. Rabinowitz. The small intestine converts dietary fructose into glucose and organic acids. Cell metabolism 27, 351-361 (2018)
• N. N. Pavlova, S. Hui, J. M. Ghergurovich, J. Fan, A. M. Intlekofer, R. M. White, J. D. Rabinowitz, C. B. Thompson and J. Zhang. As extracellular glutamine levels decline, asparagine becomes an essential amino acid. Cell metabolism 27, 1-11 (2018)

2017

• S. Hui, J. M. Ghergurovich, R. J. Morscher, C. Jang, X. Teng, W. Lu, L. A. Esparza, T. Reya, L. Zhan, J. Y. Guo, E. White and J. D. Rabinowitz. Glucose feeds the TCA cycle via circulating lactate. Nature 551, 115-118 (2017)
• M. Basan, S. Hui and J. R. Williamson. ArcA overexpression induces fermentation and results in enhanced growth rates of E. coli. Scientific Reports 7:11866 (2017)
• W. Lu, L. Wang, L. Chen, S. Hui and J. D. Rabinowitz. Extraction and quantitation of NAD(P)(H). Antioxidants and Redox Signaling (2017) doi:10.1089

2015 & earlier

• M. Basan*, S. Hui*, H. Okano, Z. Zhang, Y. Shen, J. R. Williamson and T. Hwa. Overflow metabolism in E.coli results from efficient proteome allocation. Nature 528, 99-104 (2015) [*equal contribution]
• S. Hui, J. M. Silverman, S. S. Chen, D. W. Erickson, M. Basan, J. Wang, T. Hwa#, and J. R. Williamson#. Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacterial metabolism and growth. Molecular Systems Biology 11.2 (2015)
• C. You, H. Okano*, S. Hui*, Z. Zhang, M. Kim, C. W. Gunderson, Y.-P. Wang, P. Lenz, D. Yan, and T. Hwa. Coordination of bacterial proteome with metabolism by cyclic AMP signalling. Nature 500, 301–306 (2013) [*equal contribution]
• G. Alexe, R. Vijaya Satya, M. Seiler, D. Platt, T. Bhanot, S. Hui, M. Tanaka, A. J. Levine and G. Bhanot. PCA and Clustering Reveal Alternate mtDNA Phylogeny of N and M Clades. J. Mol. Evol. 67, 465-87 (2008)
• S. Hui and L.-H. Tang. Ground state and glass transition of the RNA secondary structure. Eur. Phys. J. B 53, 77-84 (2006)