Lee Kum Sheung Center for Health and Happiness
The mission of the Lee Kum Sheung Center for Health and Happiness is to build a rigorous and interdisciplinary science of positive health, happiness, and well-being with a focus on health equity, and to translate the science to influence practice and policy.
Kresge Building 6th Floor
677 Huntington Avenue
Boston, MA 02115

Publications
Center scholars and affiliate scientists are continuously investigating the complex interrelationships between physical, social, and mental health and designing and evaluating interventions for the improvement of overall well-being across the globe. Besides the connections between these three realms of health, key areas of focus include health equity, social media, loneliness, resilience, and positive psychology.
Research by Center Scholars and Affiliates 2024-5
Abe, K., Suzuki, K., Miyawaki, A., & Kawachi, I. (2025). Impact of COVID-19 on medical utilization for psychiatric conditions in Japan. Social Science & Medicine, 367
Duncan, D.T., Kawachi, I., and Morse, S.S. (2024). The Social Epidemiology of the COVID-19 Pandemic. Oxford University Press
Durieux, N., Park, E. R., Hall, D., Meek, J., Fricchione, G., Mehta, D. H., & Luberto, C. (2025). Resiliency among Mass General Brigham Hospital employees post-COVID-19 pandemic. Global Advances in Integrative Medicine and Health
Kawachi, I. (2024). Income Inequality and COVID-19, in Duncan, D., Kawachi, I., and Morse, S. (2024). The Social Epidemiology of the COVID-19 Pandemic. Oxford University Press, USA
Chakraborty, S., Gui, M., Gerosa, T., and Marciano, L. (2024). Testing the validity of the smartphone pervasiveness scale for adolescents with self-reported objective smartphone use data. Digital Health, 10: 1-9
Patel, V., et al. (2025). Task-sharing and telemedicine delivery of psychotherapy to treat perinatal depression: A pragmatic, noninferiority randomized trial. Nature Medicine
Patel, V., et al. (2024). Scaling up the task-sharing of psychological therapies: A formative study of the PEERS smartphone application for supervision and quality assurance in rural India. Cambridge Prisms: Global Mental Health, 11(20), 1–11
Patel, V., et al. (2024). Designing an App to Support Measurement-Based Peer Supervision of Frontline Health Workers Delivering Brief Psychosocial Interventions in Texas: Multimethod Study. JMIR Formative Research, 8
Patel, V., et al. (2024). Development and Pilot Testing of PracticePal, a Conversational Agent to Support the delivery of a brief behavioural activation treatment for depression in rural India. Springer Nature
Pedersen, G., & Patel, V., et al. (2024). Development of a Remote Implementation Support Strategy to Enhance Integration of Depression Treatment into Primary Care Settings in Rural India. Frontiers in Public Health, 12
James, P., et al. (2024).Measuring Environmental and Behavioral Drivers of Chronic Diseases Using Smartphone-Based Digital Phenotyping: Intensive Longitudinal Observational mHealth Substudy Embedded in 2 Prospective Cohorts of Adults. JMIR Public Health and Surveillance
Denckla, C.A, Kubzansky, L.D., Koenen, K.C., et al. (2024). A systematic review of the effects of chronic, slow-onset climate change on mental health. Nature mental health
James, P., et al. (2025). Seasonal average temperature differences and CVD incidence: Results from the US-based Nurses’ Health Study, Nurses’ Health Study II, and the Health Professional Follow-up study. Environmental Health Perspectives
James, P., et al. (2024). Associations of street-view greenspace with Parkinson’s disease hospitalizations in an open cohort of elderly US Medicare beneficiaries. Environment International,188
James, P., et al. (2024). Abstract MP76: Street View Greenspace Exposures and Cardiovascular Health Among Children – Evidence From Project Viva. AHA Journals
James, P., et al. (2024). Abstract P394: Associations of Street-View Greenspace Exposure With Cardiovascular Health (Life’s Essential 8) Among Women in Midlife. AHA Journals
James, P., et al. (2024). Childhood exposure to air pollution, noise, and surrounding greenness and incident hypertension in early adulthood in a US nationwide cohort–the Growing Up Today Study (GUTS). Environmental Research, 263 (2)
Koenen, K.C., et al. (2025). Associations between residential segregation, ambient air pollution, and hippocampal features in recent trauma survivors
Patel, V., et al. (2024). Advancing disability-inclusive climate research and action, climate justice, and climate-resilient development. The Lancet: Planetary Health, 8(4), E242-E255
Schwartz, J., et al. (2024). Air pollution mixture exposure during pregnancy and postpartum psychological functioning: racial/ethnic- and fetal sex-specific associations. Journal of Exposure Science & Environmental Epidemiology
Krekel, C., Kavetsos, G., & Ziebarth, N. R. (2025). Passing on the flame: Do mega sports events promote health behaviours? Social Science & Medicine
Marciano, L., Kikut-Stein, A., & Viswanath, K. (2025). Communication, equity, and mental well-being: The road ahead. In M. C. Yzer & J. T. Siegel (Eds.), The handbook of mental health communication (1st ed.). John Wiley & Sons, Inc.
National Academies of Sciences, Engineering, and Medicine. (2024). Understanding and Addressing Misinformation About Science. (Viswanath, K., Taylor, T., and Rhodes, H., Eds.) Washington, DC: The National Academies Press
Adzrago, D., Elhabashy, M., Williams, D. R., & Williams, F. (2025). Psychological distress and its potential risk factors among Black and White adult immigrants in the United States – National Health Interview Survey 2005–2018. Preventive Medicine Reports, 103052
Cajita, M., Dunn, S., Hernandez, R., & Doorenbos, A. (2024). Abstract 4123509: The Intersection of Race and Ethnicity, Social Determinants of Health, and Hypertension Prevalence: A Community-Level Analysis. Circulation, 150
Denckla, C. A., et al. (2025). Multi-level socioeconomic modifiers of the comorbidity of post-traumatic stress and tobacco, alcohol, and cannabis use: The importance of income. Social Psychiatry and Psychiatric Epidemiology
Grodstein, F., et al. (2025). Sexual orientation disparities in subjective cognitive decline in a large cohort of female nurses. LGBT Health
Grodstein, F., et al. (2024). Everyday Discrimination is Associated with Higher Odds of Hospitalizations among Older African Americans. The Journals of Gerontology: Series A
Lawrence, J., Hsu, Y., Cory, H., & Kawachi, I. (2024). Racial discrimination and cognitive function: An instrumental variable analysis. Social Science & Medicine, 363
Mateo, C.M., Furtado, K., Plaisime, M.V., and Williams, D.R. (2024). The Sociopolitical Context of the Unequal Treatment Report: Then and Now. Urban Institute
Mbewu, A., Williams, D.R., Moletsane, R., and Reddy, P. (2024). Striking racial inequities in health persist in South Africa. BMJ, 385, q834
Peters, S.E., Wagner, G.R., et al. (2024). Adding injury to insult: Unfair treatment at work and occupational injury among hospital patient-care workers. American Journal of Industrial Medicine
Pinillos-Franco, S. & Kawachi, I. (2025). It’s not just your opinion, it’s a type of hate that may affect your health: the effect of homophobia on health in Europe
Qureshi, F., Denckla, C., and Boehm, J.K. (2024). Positive epidemiology, revisited: The case for centering human rights and economic justice. American Journal of Epidemiology
Williams, D.R., et al. (2024). Addressing Structural Racism Through Public Policy Advocacy: A Policy Statement From the American Heart Association. American Heart Association Journal
Ramanadhan, S., et al. (2025). Assessing equitable implementation of a social care initiative integrating medical and social services for Medicaid members. Health Services Research
Rastogi, R., Raval, V. V., Yip, T., Chen, J. A., & Liu, C. H. (2025). The effects of racial exclusion and racial othering on South Asian American identity and population health. American Journal of Public Health
Semanaz, C., Ghassabian, A., Delaney, S., Fang, F., Williams, D. R., & Tiemeier, H. (2025). Considerations when accounting for race and ethnicity in studies of poverty and neurodevelopment. Journal of the American Academy of Child & Adolescent Psychiatry
Wright, E., Dore, E. C., Koenen, K. C., Mangurian, C., Williams, D. R., & Hamad, R. (2025). Prevalence of and inequities in poor mental health across 3 US surveys, 2011 to 2022. JAMA Network Open, 8(1)
Cowden, R.G., et al. (2024). Do Forgiveness Campaign Activities Improve Forgiveness, Mental Health, and Flourishing? International Journal of Public Health, 69
Kim, E. S., Bradshaw, M., Chen, Y., Chopik, W. J., Okuzono, S. S., Wilkinson, R., Padgett, R. N., Lachman, M. E., Johnson, B. R., & VanderWeele, T. J. (2025). Characterizing the Childhood Roots of Adult Sense of Mastery Across 22 Countries in the Global Flourishing Study
Kim, E. S., Padgett, R. N., Bradshaw, M., Chen, Y., Chopik, W. J., Okuzono, S., Wilkinson, R., Lachman, M. E., Johnson, B. R., & VanderWeele, T. J. (2025). Mapping demographic variations in sense of mastery across the world: A cross-national analysis of 22 countries in the Global Flourishing Study
Kim, E. S., Wilkinson, R., Holt-Lunstad, J., & VanderWeele, T. J. (2025). Loneliness During Adolescence and Subsequent Health and Well-Being in Adulthood: An Outcome-Wide Longitudinal Approach. Journal of Adolescent Health
Kim, E.S., et al. (2024). The silent epidemic of loneliness: identifying the antecedents of loneliness using a lagged exposure-wide approach. Psychological Medicine, 1–14
Wilkinson, R., Shiba, K., Kim, E. S., Case, B., Okuzono, S., Cowden, R., Gundersen, C., Chen, Y., Padgett, R. N., Johnson, B. R., & VanderWeele, T. J. (2025). Loneliness in a global context: Sociodemographic disparities and childhood determinants
Yoshida, K., Honda, K., Goto, A., and Kawachi, I. (2024). Collateral Health Effects of Loneliness Care in Japan. Health Services Research and Managerial Epidemiology
Choi, K., et al. (2024). Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal. Psychological Medicine, 54 (11)
Choi, K., et al. (2024). Time Trends in Adolescent Diagnoses of Major Depressive Disorder and Co-occurring Psychiatric Conditions in Electronic Health Records. Research Square
Kawachi, I., et al. (2024). Pre-disaster income inequality and post-disaster mental health: A natural experiment from the 2011 Great East Japan Earthquake and Tsunami . Health & Place, 90
Papola, D. & Patel. V. (2025). Towards person-centered care in global mental health: implications for meta-analyses and clinical trials. Epidemiology and Psychiatric Sciences 34, e13, 1–5
Patel, V., et al. (2025). Effective components of collaborative care for depression in primary care: An individual participant data meta-analysis. JAMA Psychiatry
Patel, V., et al. (2024). Adapting and deploying a digital program for training non-specialist providers on a brief psychological intervention for depression in rural Gujarat, India. PLOS Global Public Health
Patel, V., et al. (2024). Depression Diagnosis, Treatment, and Remission Among Adults in India. JAMA Psychiatry
Patel, V., et al. (2024). Remote coaching for supporting the implementation of treatment for depression in primary care in Madhya Pradesh, India: protocol for a cluster randomized controlled trial. Frontiers in Health Services
Patel, V., et al. (2024). Adolescent engagement in a stepped care, transdiagnostic mental health intervention delivered in Indian schools. Discover Psychology, 4:43
Patel, V., et al. (2024). The Effects of Mental Health Interventions on Labor Market Outcomes in Low- and Middle-Income Countries. National Bureau of Economic Research
Patel, V., et al. (2024). International Representation in Psychiatric Literature: Has the Trend Changed? Review of 11 Leading Psychiatric Journals. Archives of Psychiatry Research, 60:1
Williams, D.R., et al. (2025). Treatment coverage for mental disorders: Results from the World Health Organization World Mental Health Surveys. In Oxford textbook of community mental health (2nd ed., pp. 45-56). Oxford University Press
Côté, A., Miquelon, P., and Trudel-Fitzgerald, C. (2024). Physical Activity, Sedentary Time, and Psychosocial Functioning among Adults with Cancer: A Scoping Review. International Journal of Environmental Research and Public Health, 21(2), 225
Hernandez, R., et al. (2024). Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study. Kidney Medicine, 6(4)
Kim, E.S., Wilkinson, R., Okuzono, S.S., Chen, Y., Shiba, K., Cowden, R.G., and VanderWeele, T.J. (2024). Positive affect during adolescence and health and well-being in adulthood: An outcome-wide longitudinal approach. PLOS Medicine
Kivimäki, M., & Kawachi, I. (2025). Work stress and health. In N. Schneiderman, T. W. Smith, N. B. Anderson, M. H. Antoni, F. J. Penedo, T. A. Revenson, & A. F. Abraído-Lanza (Eds.), APA handbook of health psychology, Vol. 1. Foundations and context of health psychology (pp. 611–637). American Psychological Association.
Koenen, K., et al. (2024). Identifying Genetically Inferred Effects Linking Posttraumatic Stress Disorder to Women’s Health, Lipid Disorders, and Malaria Medications. American Journal of Psychiatry, 181(12)
Koenen, K., et al. (2024). No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study. Brain, Behavior, and Immunity, 123, 672-680
Ng, A. E., Gruenewald, T., Juster, R.-P., & Trudel-Fitzgerald, C. (2025). Affect regulation and mortality risk: The role of allostatic load. Biopsychosocial Science and Medicine
Patel, V., et al. (2024). Conditional cash transfers and mortality in people hospitalised with psychiatric disorders: A cohort study of the Brazilian Bolsa Família Programme. PLOS Medicine
Patel, V., et al. (2024). Effectiveness, cost-effectiveness, and positive externalities of integrated chronic care for adults with major depressive disorder in Malawi (IC3D): a stepped-wedge, cluster-randomised, controlled trial . The Lancet, 404(10465)
Trudel-Fitzgerald, C., et al. (2024). Understanding mental health in breast cancer from screening to Survivorship: an integrative phasic Model and tool. Psychology, Health, & Medicine
Park, E., et al. (2024). Residents’ perspectives on program impact of a group-based mind-body intervention in CCRCS. Innovation in Aging
Perez, G.K., Park, E.R., et al. (2024). Development and feasibility of a virtual, synchronous mind-body resiliency intervention for fathers of children and youth with special healthcare needs. Brain Behavior and Immunity Integrative, 5
Wayne, P. M., Ahn, A., Clark, J., Irwin, M. R., Kong, J., Lavretsky, H., Li, F., & Yeh, G. Y. (2025). The science of Tai Chi and Qigong and whole person health part I: Rationale and state of the science. Journal of Integrative and Complementary Medicine
Wayne, P., et al. (2024). Tai Chi for balance and postural control in people with peripheral neuropathy: A scoping review. Complementary Therapies in Medicine
Yeh, G., et al. (2025). Pilot study protocol for a novel perioperative mind-body intervention for peripheral vascular interventions. JVS-Vascular Insights, 3, 100199. Presented at the 52nd Annual Meeting of the Society for Clinical Vascular Surgery, March 28, 2025, Austin, Texas
Joss, D., Teicher, M.H., and Lazar, S.W. (2024). Beneficial effects of mindfulness-based intervention on hippocampal volumes and episodic memory for childhood adversity survivors. Journal of Affective Disorders Reports, 16
Lazar, S.W., et al. (2024). ENIGMA-Meditation: Worldwide consortium for neuroscientific investigations of meditation practices
Lazar, S., et al. (2024). Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI. Journal of Mood and Anxiety Disorders, 9
Luberto, C., Crute, S., Wang, A., Li, R., Yeh, G., Huffman, J., Celano, C., Victorson, D., Hoeppner, B., & Park, E. (2024). Needs and Preferences for Remote-Delivered Mindfulness-Based Cognitive Therapy in Patients After Acute Coronary Syndrome: A Qualitative Study. Global Advances in Integrative Medicine and Health, 13, 1-10
Wayne, P.M., Yeh, G.Y., and Mehta, D.H. (2024). Through the Looking Glass: Psychedelics As a Window into Mindfulness and Mind–Body Health. Journal of Integrative and Complementary Medicine, 30: 1
Chen, Y., Nakamura, S., Kim, E., Kubzansky, L., & VanderWeele, T. (2024). Changes in optimism and subsequent health and wellbeing outcomes in older adults: an outcome-wide analysis. Aging & Mental Health
Huffman, J.C., et al. (2024). Gratitude, optimism, and satisfaction with life and patient-reported outcomes in patients undergoing hematopoietic stem cell transplantation. Psycho-Oncology, 33 (2)
Koga, H.K., Grodstein, F., Williams, D.R., et al. (2024). Longitudinal Associations Between Optimism and Objective Measures of Physical Functioning in Women. JAMA Psychiatry
Oh, J., Tetreau, E., Purol, M., Kim, E., & Chopik, W. (2024). Optimism and pessimism were prospectively associated with adaptation during the COVID-19 pandemic. Journal of Research in Personality, 113
Carlon, H. A., Hurlocker, M. C., Hoeppner, B. B., & Witkiewitz, K. (2025). Positive psychological interventions for substance use, addiction, and recovery: An updated systematic review and meta-analysis. Addiction
Huffman, J.C., et al. (2024). Gratitude, optimism, and satisfaction with life and patient-reported outcomes in patients undergoing hematopoietic stem cell transplantation. Psycho-Oncology, 33 (2)
Hernandez, R., & Huffman, J. C., et al. (2025). Impacts of a church-based positive psychological intervention in Spanish-speaking Hispanics/Latinos with uncontrolled hypertension: Results from the ¡Alegrate! randomized clinical trial. Journal of Happiness Studies, 26 (24)
Koga, H.K., Grodstein, F., Williams, D.R., et al. (2024). Longitudinal Associations Between Optimism and Objective Measures of Physical Functioning in Women. JAMA Psychiatry
Krentzman, A., Hoeppner, S., Hoeppner, B., Barnett, N.P. (2024). A randomized feasibility study of a positive psychology journaling intervention to support recovery from substance-use disorders. Journal of Substance Use and Addiction Treatment
Waldinger, R.J., et al. (2024). More organized white matter is associated with positivity bias in older adults. Brain Imaging and Behavior
Choi, K., et al. (2025). Multisystemic resilience and its impact on youth mental health: Reflections on co-designing a multi-disciplinary, participatory study. Frontiers in Child and Adolescent Psychiatry, 4
Choi, K., et al. (2025). Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults. Journal of Mood & Anxiety Disorders
Dijk, S. W., Krijkamp, E., & Hunink, M. (2025). Economic evaluation of resilience training for medical students: A cohort state-transition model. Medical Teacher
Kawachi, I., et al. (2024). Resilience factors affecting long-term trajectories of depressive symptoms in the aftermath of the Great East Japan Earthquake and Tsunami among older adults. The Journals of Gerontology
Park, E., et al. (2024). B – 97 On the Rebound: Resilience and Subjective Cognitive Concerns in Cancer | Archives of Clinical Neuropsychology. Archives of Clinical Neuropsychology, 39(7),1197
Park, E., et al. (2024). A resiliency intervention adapted for older women with HIV: Results from a pilot randomized controlled trial in the northeastern US. Journal of Health Psychology
Sampson, L., Scoglio, A. A. J., Nishimi, K., Choi, K., Kim, A. H., Zhu, Y., Sun, Q., Kang, J. H., Rimm, E. B., Koenen, K. C., & Kubzansky, L. D. (2025). Psychological resilience to trauma and longitudinal sleep outcomes among current and former nurses. Journal of Psychosomatic Research, 192, 112090
Scoglio, A., Nishimi, K., Choi, K., Koenen, K., Sampson, L., Jha, S., and Kubzansky, L. (2024). Prior resilience to trauma & coping during the COVID-19 pandemic. PLOS One
Yeh, G., Park, W., et al. (2024). Pilot Randomized Controlled Trial of IN FOCUS: A Mind‐Body Resiliency Intervention for Fear of Cancer Recurrence . Psycho-Oncology, 33(11)
Kim, E. S., Bradshaw, M. ,Padgett, R. N., Chen, Y., Shiba, K., Ritchie-Dunham, J. L., Case, B. W., Johnson, B. R., & VanderWeele, T. J. (2025). Identifying Childhood Correlates of Adult Purpose and Meaning Across 22 Countries (Global Flourishing Study)
Kim, E., et al. (2024). Measuring meaning in life by combining philosophical and psychological distinctions: Psychometric properties of the Comprehensive Measure of Meaning. The Journal of Positive Psychology
Koga, H.K., Grodstein, F., Williams, D.R., Buchman, A.S., and Kubzansky, L.D. (2024). Purpose in life and its association to Parkinsonism. The Journals of Gerontology: Series B
Chen, J. et al. (2025). It takes a village: Social engagement with family is associated with reduction in postpartum depression during psychotherapy
Hikichi, H., Kondo, K., & Kawachi, I. (2024). Associations between community social capital and posttraumatic growth among older survivors 11 years after a natural disaster. American Journal of Epidemiology
Hsu, Y., Grodstein, F., Liu, T., Chang, C., Kawachi, I., & Chen, J. T. (2025). Causal mediation of the association between educational attainment and late-life cognitive function by trajectories of social participation. Social Science & Medicine, 370, 117861
Huffman, J., (2024). A peer support intervention in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT): The STEPP randomized pilot trial design and methods. Contemporary Clinical Trials, 148
Kim, E.S., et al. (2024). A national cohort study of community belonging and its influence on premature mortality. Journal of Epidemiology & Health
Koenen, K., et al. (2025). The relationship between social adversity, micro-RNA expression and post-traumatic stress in a prospective, community-based cohort
Viswanath, K., et al. (2025). Improving Mental Health Among Indian Adolescents: Evidence From an Innovative Adolescent Peer-Led Intervention in Rajasthan, India. Journal of Adolescent Health, 76(3)
Williams, D. R., et al. (2025). The role of religiosity and spirituality in coping with sickle cell disease clinical severity. Journal of Sickle Cell Disease, 2(1)
Koenen, K.C., Denckla, C.M., et al. (2025). Multi-level socioeconomic modifiers of the comorbidity of post-traumatic stress and tobacco, alcohol, and cannabis use: the importance of income. Social Psychiatry and Psychiatric Epidemiology
Liu, Y., & Marciano, L. (2024). Appnome analysis reveals small or no associations between social media app-specific usage and adolescent well-being. Scientific Reports, 14 (30836)
Marciano, L., Dubicka, B., Magis-Weinberg, L., Morese, R., Viswanath, K., & Weber, R. (2024). Digital Media, Cognition, and Brain Development in Adolescence. In D. A. Christakis, L. Hale (eds.), Handbook of Children and Screens, (21-29). Springer
Marciano, L., et al. (2024). User-Donated Screenshots Analysis: Feasibility of a New Approach to Collect Objective Social Media App Usage in Adolescents. In: Thomson, R., et al. Social, Cultural, and Behavioral Modeling,14972, 80-89. Springer
Marciano, L., Jindal, S., & Viswanath, K. (2024). Digital Detox and Well-Being. Pediatrics, 154 (4)
Marciano, L., et al. (2024). Safeguarding young users on social media through academic oversight. Nature Reviews Psychology
Mendez, S., Munoz-Najar, S., Emmons, K., & Viswanath, K. (2024). Journal of Medical Internet Research – US State Public Health Agencies’ Use of Twitter From 2012 to 2022: Observational Study. Journal of Medical Internet Research, 27
Long, K., Wilkinson, R., Cowden, R.G., Chen, Y., and VanderWeele, T.J. (2024). Hope in adolescence and subsequent health and well-being in adulthood: An outcome-wide longitudinal study. Social Science & Medicine, 347
Park, E.R., et al. (2025). Development of the bi-directional engagement strategy tool (BEST) to assist implementation of wellness programs in federally qualified health centers. Crisis, Stress, and Human Resilience: An International Journal, 6(3)
Wang, K., Goldenberg, A., Lerner, J. S., & Gross, J. J. (2025). Enhancing workplace well-being through reappraisal in a nationwide field experiment
Wu, C., & Kawachi, I. (2024). A triple trust penalty? The majority-minority gap in subjective wellbeing. Social Science & Medicine