Fine-Mapping Causal Tissues and Genes at Disease-Associated Loci
VirtualAbstract: Complex diseases often have distinct mechanisms spanning multiple tissues. We propose Tissue-Gene Fine-Mapping (TGFM), which infers the posterior probability (PIP) for each gene-tissue pair to mediate a disease locus by analyzing summary statistics and eQTL data; TGFM also assigns PIPs to non-mediated variants. TGFM accounts for co-regulation across genes and tissues and models uncertainty...