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Fine-Mapping Causal Tissues and Genes at Disease-Associated Loci

Virtual

Abstract: Complex diseases often have distinct mechanisms spanning multiple tissues. We propose Tissue-Gene Fine-Mapping (TGFM), which infers the posterior probability (PIP) for each gene-tissue pair to mediate a disease locus by analyzing summary statistics and eQTL data; TGFM also assigns PIPs to non-mediated variants. TGFM accounts for co-regulation across genes and tissues and models uncertainty...

Building Foundations: Addressing Housing Insecurity to Improve Child Health

Virtual

Abstract: The ongoing housing affordability crisis in the US poses significant challenges to the wellbeing of children. In this presentation, I will provide an overview of the relationship between housing instability and children's health drawing on a range of recent studies. I will also describe evidence from both quasi-experimental and experimental research to demonstrate how...