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Quantitative Issues in Cancer Research Working Group Seminar

Building 2, Room 426

Kimberly Greco, PhD Student, Department of Biostatistics, Harvard T.H. Chan School of Public Health Graph Attention Framework to Enhance Rare Disease Sub-Phenotyping from EHR Abstract: Accurately sub-phenotyping patients according to their risk for an adverse clinical outcome can significantly enhance clinical decision-making. Recent advances in patient representation learning have enabled the development of sophisticated clustering...

Quantitative Issues in Cancer Research Working Group Seminar

Building 2, Room 426

Elizabeth Graff, PhD Student, Department of Biostatistics, Harvard T.H. Chan School of Public Health Applications of Deep Learning for Graph-Structured Data: From Disease Spread to Social Networks Abstract: How can we apply deep learning to solve problems in modeling the spread of disease? In this talk, we will explore the components and applications of Graph...

PQG Seminar

Building 2, Room 426

Ruben Dries Assistant Professor, Medicine Boston University Towards Solutions for Large-Scale Multi-Modal Spatial Data Analysis In the burgeoning field of spatial biology, the integration of multi-modal spatial omics technologies presents both a formidable challenge and a tremendous opportunity for advancing clinical research and diagnostics. I will discuss the concerted efforts of our laboratory to address...

Quantitative Issues in Cancer Research Working Group Seminar

Building 2, Room 426

Christian Covington, PhD Student, Department of Biostatistics, Harvard T.H. Chan School of Public Health Statistical theory and the practice of data analysis: A brief and biased history Abstract: This talk gives an account of the replication crisis and how different disciplines– namely applied sciences, statistics, and theoretical computer science (TCS), have developed their own research...

Quantitative Issues in Cancer Research Working Group Seminar

Building 2, Room 426

Mónica Robles Fontán, PhD Student, Department of Biostatistics, Harvard T.H. Chan School of Public Health Leveraging Record Linkage To Enhance Public Health Research Abstract: Record linkage is the task of combining records from different populations that belong to a single entity to create a new single population. This task allows researchers to take advantage of...

HIV Working Group Seminar

Building 2, Room 426

Tanayott (Tony) Thaweethai Associate Director for Biostatistics Research and Engagement, Massachusetts General Hospital Biostatistics Development of a symptom-based definition of long COVID using negative-unlabeled data Abstract: While most people infected with COVID-19 recover after the acute phase of infection, some people continue to experience persistent symptoms months and even years after infection. These symptoms, also...

Quantitative Issues in Cancer Research Working Group Seminar

Building 2, Room 426

Sajia Darwish, PhD Student, Department of Biostatistics, Harvard T.H. Chan School of Public Health Discussion of “What is the probability of replicating a statistically significant effect?” (Miller 2009) Abstract: If an initial experiment produces a statistically significant effect, what is the probability that this effect will be replicated in a follow-up experiment? argues that this...

PQG Student and Postdoc Seminar

Building 2, Room 426

Kodi Taraszka Research Fellow in Medicine Dana-Farber Cancer Institute COX proportional hazards Mixed Model (COXMM) accurately estimates the heritability of time-to-event traits With large biobanks connecting electronic health records with genetic sequencing, our understanding of the genetic architecture of time-to-event (TTE) traits such as age-of-onset, treatment response, and disease progression has grown. As a result,...

Quantitative Issues in Cancer Research Working Group Seminar

Building 2, Room 426

Phillip Nicol, PhD Student, Department of Biostatistics, Harvard T.H. Chan School of Public Health Estimation in Poisson log-bilinear models Abstract: The Poisson log-bilinear model, also known as GLM-PCA, is a commonly used approach for dimension reduction in single-cell RNA-seq data. Model parameters are usually estimated via maximum likelihood. However, we show that the MLE can...