Grad Lab
Our lab studies how pathogens evolve and spread. We use experimental and computational tools to test our hypotheses and collaborate with clinical and public health institutions. Our overall aim is to improve diagnostics, therapeutics, and clinical and public health strategies to aid in the control of infectious diseases.
Harvard T.H. Chan School of Public Health
665 Huntington Avenue,
Building 1, Room 715
Boston, MA 02115
People
Yonatan Grad
Yonatan is Professor of Immunology and Infectious Diseases at the Harvard TH Chan School of Public Health, and faculty in the Division of Infectious Diseases at Brigham and Women’s Hospital. He earned his MD and PhD at Harvard Medical School, trained in internal medicine at BWH and infectious diseases at BWH and Massachusetts General Hospital, and did his postdoctoral work in the Center for Communicable Disease Dynamics at the Chan School.
The Grad lab focuses on how to prepare and respond effectively to infectious disease threats through understanding interacting processes from microbial evolution through human ecology. The lab uses interdisciplinary methods, including microbial genetics, population genomics, and mathematical modeling to move across these scales, with goals of advancing clinical and public health practices.
Researchers
Sofia is currently studying fitness costs associated with resistance to new antibiotics in Neisseria gonorrhoeae.
Aditi’s work focuses on the antigenic diversity of Neisseria gonorrhoeae and its interaction with host immunity.
Sam’s current research focuses on using genetic approaches to understand and exploit fitness costs associated with the acquisition of antimicrobial resistance in Neisseria and Streptococcus.
Mui focuses on defining trends in antibiotic use and resistance, modeling antibiotic use and resistance, using data from the US Veterans Health Administration and from the Alberta Health Services in Canada.
Postdoctoral Fellows
Aditya works on understanding mechanisms of drug resistance in N. gonorrhoeae.
David works on questions about the genomics of antibiotic resistance in N. gonorrhoeae.
Tse Yang (T.Y.) Lim is a complex systems modeler who develops simulation models of public health problems to inform policy decision processes. His recent work has focused on substance use and the opioid crisis, as well as the COVID-19 pandemic. He received his PhD from the system dynamics group at the MIT Sloan School of Management, and was previously an ORISE Fellow at the US Food and Drug Administration. He also holds a BS and Master’s in Environmental Management from Yale.
Kirstin models genomic surveillance strategies for the control of infectious diseases using a combination of simulation-based and statistical methods. She recently completed her PhD in Computational Mathematics at the University of São Paulo, where she applied machine learning and causal inference to study the spread of vector-borne diseases in Brazil. Prior to her PhD studies, Kirstin was a data scientist at the World Bank Group and has worked on international development projects in Latin America, Sub-Saharan Africa, and Asia.
Jonathan is a resident physician at Massachusetts General Hospital. He is interested in the action of cell wall inhibitors in N. gonorrhoeae.
QinQin studies how the evolution and spread of N. gonorrhoeae is shaped by adaptive immunity and also investigates the equitability of wastewater surveillance.
Students
Alec is a PhD student in Population Health Sciences specializing in infectious disease epidemiology. His current research interests include modeling infectious disease dynamics under targeted policy interventions to improve methods for tracking disease transmission.
Bailey Bowcutt is a PhD student in the Biological Sciences in Public Health Program, advised by Dr. Yonatan Grad. She is interested in antibiotic resistance in Neisseria gonorrhoeae, specifically involving drug-drug interactions and mutation interactions related to the two new antibiotics for Neisseria gonorrhoeae that are being released. Bailey holds a B.S. in Microbiology with a minor in Global Public Health and Epidemiology from Michigan State University. She has also trained at the Wyoming Public Health Labs researching antibiotic resistance in Shiga Toxin-producing E. coli and assisting with wastewater and clinical SARS-CoV-2 testing. Outside of work, she loves drinking tea, eating ice cream as often as humanly possible, and learning ballet.
Maddy is a second-year PhD student in the Population Health Sciences program in Infectious Disease Epidemiology, and a fourth-year student in the MD-PhD program advised by Dr. Yonatan Grad. She is interested in genomic epidemiology and mathematical modelling, especially of Group A Streptococcus, and also in the impact of climate change on infectious diseases.
Eric is interested in both immunity to N. gonorrhoeae and developing experimental methods to capture pathogen genomics.
Join the Grad Lab
Our goal is to do high-quality research that addresses key questions about pathogens and infectious diseases within an environment that emphasizes collaboration and innovation. We welcome applications from skilled, motivated, and independent researchers at all levels.
Undergraduates interested in joining the lab should have an interest in programming, wet lab research, or a combination of both. Proficiency in at least one programming language (such as Perl, Python, R, Matlab, C(++), or Java) and biological background in at least one research area are pluses. Please read recent papers from the lab to confirm that the lab’s work aligns with your interests.
Senior researchers and postdoctoral fellows are welcome to contact Yonatan about opportunities. Postdoctoral applicants should provide a CV and contacts for three letters of recommendation.