Grad Lab
Our lab studies how pathogens evolve and spread. We use experimental and computational tools to test our hypotheses and collaborate with clinical and public health institutions. Our overall aim is to improve diagnostics, therapeutics, and clinical and public health strategies to aid in the control of infectious diseases.Â
Harvard T.H. Chan School of Public Health
665 Huntington Avenue,
Building 1, Room 715
Boston, MA 02115
Our Research
Our lab studies how pathogens evolve and spread. We use experimental and computational tools to test our hypotheses, and collaborate with clinical and public health institutions. We focus on questions of antibiotic resistance, within-host evolution and between-host transmission, and pathogen response to host immune pressures. Our overall aim is to improve diagnostics, therapeutics, and clinical and public health strategies to aid in the control of infectious diseases.



Our Research
We use molecular microbiology, experimental evolution, and pathogen population genomics techniques to discover and characterize genetic modulators of antibiotic resistance in N. gonorrhoeae, including for new antibiotics under development, to inform treatment strategies, diagnostics, and surveillance.
We use mathematical modeling and statistical analyses to characterize the spatiotemporal trends of pathogen transmission and the impacts of antibiotic use, diagnostics, vaccination, and other interventions, with the goal of informing policies for disease control and prevention.
We work with large datasets from population genomics, insurance claims, clinical diagnostics, wastewater, and other sources to design, interpret, optimize, and assess the effectiveness of disease surveillance strategies.
We use molecular microbiology, immunology, and genomics tools to investigate how N. gonorrhoeae evades host immune pressures, with the goal of informing the design and rollout of a gonorrhea vaccine.
We use microscopy, molecular microbiology, and genetics to understand the basic cell biology of N. gonorrhoeae, addressing such questions as how does N. gonorrhoeae stay a diplococcus as it divides? What are the cell division mechanisms that govern this characteristic appearance?
We characterize the within-host dynamics of SARS-CoV-2 over the course of infection to understand the impact of vaccination, infection, and host heterogeneity on viral kinetics.
