From Clinical Insight to Preclinical Innovation: Advancing Next-Generation CAR T-Cell Therapies
Title Talk
“From Clinical Insight to Preclinical Innovation: Advancing Next-Generation CAR T-Cell Therapies”
THIS SPEAKER WILL BE IN PERSON IN FXB 301.
The event will be hybrid.
Speaker Information
This seminar will present an integrated clinical and translational investigation into the mechanisms that govern CAR T-cell efficacy and therapeutic resistance. We will discuss high-dimensional transcriptional and functional analyses of CAR T cells collected from patients, aimed at defining molecular programs that distinguish durable responders from those who experience relapse or non-response. Complementing these patient-based studies, we will highlight our translational preclinical work using an immunocompetent non-human primate model to experimentally interrogate causal pathways and evaluate targeted genetic modifications that enhance in vivo CAR T-cell persistence, trafficking, and antitumor activity. Together, these complementary approaches aim to establish a mechanistic foundation for the rational engineering of next-generation CAR T-cell therapies with improved clinical outcomes.
ⓘ Harvard Chan School hosts a diverse array of speakers, invited to share both scholarly research and personal perspectives. They do not speak for the School, and hosting them does not imply endorsement of their views, organizations, or employers.