Bacterial quorum sensing controls the CD8+ T cell response to skin commensals
Title Talk
“Bacterial quorum sensing controls the CD8+ T cell response to skin commensals”
THIS SPEAKER WILL BE IN PERSON IN FXB 301.
The event will be hybrid.
Speaker Information
Some strains of Staphylococcus can elicit a CD8+ T cell response upon skin colonization, without infection or inflammation. Colonizing skin with engineered versions of these strains can redirect the host T cells against any antigen of choice, protecting the host from cancer or systemic infection. We now dissect the bacterial and host molecular mechanisms underlying this unusual commensal-specific T cell response. We aim to understand the fundamental mechanisms of skin microbiome-immune crosstalk and engineer this crosstalk into novel immunotherapies.
ⓘ Harvard Chan School hosts a diverse array of speakers, invited to share both scholarly research and personal perspectives. They do not speak for the School, and hosting them does not imply endorsement of their views, organizations, or employers.