PQG Seminar
Building 2, Room 426Seunggeun 'Shawn' Lee Adjunct Professor, Biostatistics University of Michigan Rare variant association analysis Rare variants significantly impact complex diseases. This presentation will first introduce SAIGE-GENE and SAIGE-GENE+, methodologies extending SAIGE to gene/region-based rare variant tests. These methods efficiently utilize mixed effects models to adjust for sample relatedness and saddlepoint approximations to account for case-control imbalance....