Pardis Christine Sabeti

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Biography

Dr. Sabeti's lab focuses on developing new analytical and genomic methods to study evolutionary adaptation and genetic diversity in humans and pathogens, with three current research foci: (1) Identifying and characterizing the underlying adaptive changes that have shaped the human species over time; and (2) Investigating genetic diversity in pathogens such as Lassa virus, Ebola virus, Zika virus, and Babesia microti, towards improved diagnostics, surveillance, and interventions, and (3) Developing novels tools to detect and diagnose microbes causing human morbidity and mortality.

Dr. Sabeti's computational genomic lab has contributed to widely varying fields — including human evolutionary biology, gene therapy, microbial sequencing, information theory, and disease surveillance. They aim to create comprehensive approaches for detecting, containing, and treating deadly infectious diseases, including Lassa virus, Ebola virus, Zika virus, and SARS-CoV-2. She has invested in capacity building and education throughout, co-founding the African Center for Excellence of Genomic of Infectious Disease, enabling the first diagnosis of Ebola in Sierra Leone and Nigeria, training thousands of scientists through extended educational programs, and establishing genome centers in West Africa.

Education and Training

• B.S.,
  M.I.T.
• M.Sc.,
  University of Oxford
• D.Phil.,
  University of Oxford
• M.D.,
  Harvard Medical School

Publications

• Genomics reveals zoonotic and sustained human Mpox spread in West Africa.

  Parker E, Omah IF, Djuicy DD, Magee A, Tomkins-Tinch CH, Otieno JR, Varilly P, Ayinla AO, Sijuwola AE, Ahmed MI, Ope-Ewe OO, Ogunsanya OA, Olono A, Saibu FM, Eromon P, Moumbeket Yifomnjou MH, Messanga Essengue LL, Yonga MGW, Essima GD, Touoyem IP, Mounchili LJM, Eyangoh SI, Etoundi AGM, Esso L, Nguidjol IME, Metomb SF, Chebo C, Agwe SM, Mossi HM, Bilounga CN, Akanbi O, Egwuenu A, Ehiakhamen O, Chukwu C, Suleiman K, Akinpelu A, Ahmad A, Imam KI, Ojedele R, Oripenaye V, Ikeata K, Adelakun S, Olajumoke B, O'Toole Á, Zeller M, Gangavarapu K, Park DJ, Mboowa G, Tessema SK, Tebeje YK, Folarin O, Happi A, Lemey P, Suchard MA, Andersen KG, Sabeti P, Rambaut A, Ihekweazu C, Jide I, Adetifa I, Njouom R, Happi CT. Nature 2025 May 19

  PMID: 40388983

• Geospatial and demographic patterns of SARS-CoV-2 spread in Massachusetts from over 130,000 genomes.

  Moreno GK, Brock-Fisher T, Krasilnikova LA, Schaffner SF, Burns M, Casiello CE, Messer KS, Petros B, Specht I, DeRuff KC, Siddle KJ, Loreth C, Fitzgerald NA, Rooke HM, Gabriel SB, Smole S, Wohl S, Park DJ, Madoff LC, Brown CM, MacInnis BL, Sabeti PC. medRxiv 2025 Apr 06

  PMID: 40236398

• JUNIPER: Reconstructing Transmission Events from Next-Generation Sequencing Data at Scale.

  Specht I, Moreno GK, Brock-Fisher T, Krasilnikova LA, Petros BA, Pekar JE, Schifferli M, Fry B, Brown CM, Madoff LC, Burns M, Schaffner SF, Park DJ, MacInnis BL, Ozonoff A, Varilly P, Mitzenmacher MD, Sabeti PC. Res Sq 2025 Mar 27

  PMID: 40196005

• Establishing Methods to Monitor Influenza (A)H5N1 Virus in Dairy Cattle Milk, Massachusetts, USA.

  Stachler E, Gnirke A, McMahon K, Gomez M, Stenson L, Guevara-Reyes C, Knoll H, Hill T, Hill S, Messer KS, Arizti-Sanz J, Albeez F, Curtis E, Samani P, Wewior N, O'Connor DH, Vuyk W, Khoury SE, Schnizlein MK, Rockey NC, Broemmel Z, Mina M, Madoff LC, Wohl S, O'Connor L, Brown CM, Ozonoff A, Park DJ, MacInnis BL, Sabeti PC. Emerg Infect Dis 2025

  PMID: 40138725

• JUNIPER: Reconstructing Transmission Events from Next-Generation Sequencing Data at Scale.

  Specht I, Moreno GK, Brock-Fisher T, Krasilnikova LA, Petros BA, Pekar JE, Schifferli M, Fry B, Brown CM, Madoff LC, Burns M, Schaffner SF, Park DJ, MacInnis BL, Ozonoff A, Varilly P, Mitzenmacher MD, Sabeti PC. medRxiv 2025 Mar 05

  PMID: 40093219