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Park Lab

Research at the Park Lab is focused on understanding the role of the airway epithelium in the lung. As the primary barrier against external stimuli—ranging from environmental pollutants and allergens to bacteria and viruses—the airway epithelium serves as the first line of defense for respiratory health. 

Phone 617-432-2726
Location

665 Huntington Avenue
Building 1, Room 306
Boston, MA 02115

Publications

Selected Publications by Year

2024

  1. Solan ME and Park JA. Per- and poly-fluoroalkyl substances (PFAS) effects on lung health: a perspective on the current literature and future recommendations. Frontiers in Toxicology. 2024 Jul 18:6:1423449. 
  2. Park JA. E-cad that’s a Big Switch! From epithelial membrane to asthma mediator. Am J Respir Cell Mol Biol. 2024 Aug 1.
  3. Marrocco A, Mitchel JA, Parker M, McGill M, Chase RP, Weiss ST, Gold DR, Castaldi PJ, Israel E, Park JA*, Sordillo J*. Transcriptomic Profiles of Well-Differentiated Airway Epithelial Cells in Response to Environmental Triggers of Asthma Exacerbation. Allergy. 2024 Aug 7. *Co-corresponding authors. Featured on Allergy’s social media [https://youtu.be/b997bf_yxPI?si=XLGenCKCNGjW_q38]
View All Publications on PubMed

2023

  1. Dy ABC, Girkin J, Marrocco A, Collison A, Mwase C, O’Sullivan MJ, Phung TN, Mattes J, Koziol-White C, Gern JE, Bochkov YA, Bartlett NW, Park JA. Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models. Respiratory Research. 2023. 24: 205.
  2. Phung TN, Mitchel JA, O’Sullivan MJ, Park JA. Quantification of basal stem cell elongation and stress fiber accumulation in the pseudostratified airway epithelium during the unjamming transition. Biol Open, 2023 Apr 4.
  3. Mackman N, Hisada Y, Park JA. Western blot and immunohistochemical analysis of mouse tissue factor. Res Pract Thromb Haemost. 2023 Nov 2;7(8):102249.

2022

  1. Mwase C, Phung TN, O’Sullivan MJ, Mitchel JA, De Marzio M, Kılıç A, Weiss ST, Fredberg JJ, Park JA. Mechanical Compression of Human Airway Epithelial Cells Induces Release of Extracellular Vesicles Containing Tenascin C. Cells. 2022 Jan 13;11(2).
  2. Park JA, Alexander LEC, Christiani DC. Vaping and Lung Inflammation and Injury. Rev. Physiol. 2022. Feb 10;84:611-629.

2021

  1. Park HR, Vallarino J, O’Sullivan M, Wirth C, Panganiban RA, Webb G, Shumyatcher M, Himes BE, Park JA, Christiani DC, Allen J, Lu Q. Electronic cigarette smoke reduces ribosomal protein gene expression to impair protein synthesis in primary human airway epithelial cells. Sci Rep. 2021 Sep 1;11(1):17517. doi: 10.1038/s41598-021-97013-z.
  2. De Marzio M, Kılıç A, Maiorino E, Mitchel JA, Mwase C, O’Sullivan MJ, McGill M, Chase R, Fredberg JJ, Park JA, Glass K, Weiss ST. Genomic signatures of the unjamming transition in compressed human bronchial epithelial cells. Sci Adv. 2021 Jul;7(30). doi: 10.1126/sciadv.abf1088.
  3. O’Sullivan MJ*, Mitchel JA*, Mwase C, McGill M, Kanki P, Park JA. In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2021 Feb 1;320(2):L246-L253.  doi: 10.1152/ajplung.00423.2020.  (*equally contributed)

2020

  1. O’Sullivan MJ, Phung TN, Park JA. Bronchoconstriction: a potential missing link in airway remodelling. Open Biology. 2020 Dec;10(12):200254. Epub 2020 Dec 2.
  2. Mitchel JA*, Das A*, O’Sullivan MJ, Stancil IT, DeCamp SJ, Koehler S, Ocaña OH, Butler JP, Fredberg JJ, Nieto MA, Bi D, Park JA. In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition. Nature Communications, 2020, Oct 7. (*equally contributed)
  3. O’Sullivan MJ, Mitchel MA, Das A, Koehler S, Levine H, Bi D, Nagel ZD, Park JA. Irradiation induces epithelial cell unjamming. Frontiers in Cell and Developmental Biology, 2020 Feb 11;8:21.
  4. Kilic A*, Ameli A*, Park JA*, Kho AT, Tantisira K, Santolini M, Cheng F, Mitchel JA, McGill M, O’Sullivan MJ, De Marzio M, Sharma A, Scott Randell SH, Drazen JD, Jeffrey Fredberg JJ, Weiss ST. Mechanical forces induce an asthma gene signature in healthy airway epithelial cells. Scientific Reports, 2020, Jan 22;10(1):966.  (*equally contributed)

2019

  1. Kim SH, Mitchel JA, McGill M, Cremona TP, Baek J, Kasahara DI Anathy V, Israel E, Park JA. Elevated extracellular maspin after mechanical compression in vitro or allergen challenges in vivo.   Journal of Allergy and Clinical Immunology. 2019, Jun 19. pii: S0091-6749(19)30801-2. doi: 10.1016/j.jaci.2019.06.006. [Epub ahead of print]

2018

  1. Grainge C, Park JA. Inflammatory insights into airway remodelling in asthma. Respirology. 2018, Dec;23(12):1084-1085.
  2. Lan B*, Mitchel JA*, O’Sullivan MJ,  Park CY, Kim JH, Cole WC, Butler JP, Park JA. Airway epithelial compression promotes airway smooth muscle proliferation and contraction. American Journal of Physiology: Lung Cellular and Molecular Physiology. (*equally contributed) 2018, Nov 1;315(5):L645-L652. https://doi.org/10.1152/ajplung.00261.2018.
  3. Atia L, Bi D, Sharma A, Mitchel JA, Gweon B, Koehler SA, DeCamp SJ, Lan B, Kim JH, Hirsch R, Pegoraro AF, Lee KH, Starr JR, Weitz DA, Martin AC, Park JA, Butler JP, Fredberg JJ. Geometric constraints during epithelial jamming. Nature Physics. 2018, Jun;14:613-620.

2016

  1. Park JA, Atia L, Mitchel JA, Fredberg JJ, Butler JP. Collective migration and cell jamming in asthma, cancer and development. Journal of Cell Science. 2016, Sep 15;129(18):3375-83.
  2. Mitchel JA, Antoniak S, Lee JH, Kim SH, McGill M, Randell SH, Israel E, Shore SA, Mackman N, Park JA. IL-13 augments compressive stress-induced tissue factor expression in human airway epithelial cells. American Journal of Respiratory Cellular and Molecular Biology. 2016, Apr;54(4):524-31.
  3. Park JA, Fredberg JJ. Cell jamming in the airway epithelium. Annals of the American Thoracic Society. 2016, Mar;13 Suppl 1:S64-7.
  4. Pegoraro AF, Fredberg JJ, Park JA. Problems in biology with many scales of length: Cell-cell adhesion and cell jamming in collective cellular migration. Experimental Cell Research. 2016, Apr 10;343(1):54-9.

2015

  1. Park JA†*, Kim JH*, Bi D, Mitchel JA, Qazvini NT, Tantisira K, Park CY, McGill M, Kim SH, Gweon B, Notbohm J, Steward R, Burger B, Randell SH, Kho AT, Tambe DT, Hardin C, Shore SA, Israel E, Weitz DA, Tschumperlin DJ, Henske EP, Weiss ST, Manning ML, Butler JP, Drazen JM, Fredberg JJ. Unjamming and cell shape in the asthmatic airway epithelium. Nature Materials. (†corresponding author, *equally contributed), 2015, Oct;14(10):1040-8.
  2. Park JA, Fredberg JJ, Drazen JM. Putting the squeeze on airway epithelia. Physiology. 2015, Jul;30(4):293-303.

2009 – 2013

  • Park JA, Tschumperlin DJ. Chronic intermittent mechanical stress increases MUC5AC protein expression. American Journal of Respiratory Cellular and Molecular Biology. 2009, 41(4):459-66
  • Park JA, Sharif AS, Shiomi T, Kobzik L, Kasahara DI, Tschumperlin DJ, Voynow JA, Drazen JM. Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2013, 304(10):L701-7.
  • Park JA, Sharif AS, Tschumperlin DJ, Lau LC, Limbrey R, Howarth PH, Drazen JM. TF-bearing exosome from mechanically-stimulated human bronchial epithelial cells in vitro and in vivo. Journal of Allergy and Clinical Immunology. 2012, 130(6):1375-83.
  • Park JA, Drazen JM, Tschumperlin DJ. The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. Journal of Biological Chemistry. 2010, 285(39):29817-25.

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