Wendy Garrett

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Biography

Wendy Garrett is the Irene Heinz Given Professor of Immunology and Infectious Diseases in the Departments of Immunology and Infectious Diseases and of Molecular Metabolism at the Harvard Chan School of Public Health, and also has a Professorship in the Departments of Medicine at Harvard Medical School. Dr. Garrett pursued an MD and PhD at Yale University. She completed a fellowship at the Dana-Farber Cancer Institute and postdoctoral training at Harvard University Medical School.

Dr. Garrett investigates host-microbiota interactions in health and disease. Her research team studies the interplay between the gastrointestinal immune system and the gut microbiota in health, inflammatory bowel disease (IBD) and colorectal cancer (CRC). The Garrett lab focuses on how the gut microbiota influence both innate and adaptive populations and the contribution of these cells to immune homeostasis and disease.

Dr. Garrett's team has identified specific species, pathways, and metabolites made by the microbiota that influence health and disease states. The lab also studies microbes and immune cells that are not only instrumental in potentiating carcinogenesis but are integral to intestinal homeostasis. The multi-faceted research approach includes meta'omics, microbiology, cellular immunology, biochemistry, cell biology, and cancer biology. The lab uses mouse models, human specimens, and primary and transformed mammalian cells and bacterial cells in their experiments in order to move facilely between large human data sets and in vivo and in vitro model systems with a core mission of determining basic biologic mechanism and applying the findings to precision medicine.

The Garrett lab is highly collaborative and works with many laboratories at institutions in the greater Boston area, in Harvard-affiliated hospitals and institutes, and at national and international research centers.

Education and Training

• B.S./ M.S., , Combined Bachelor of Science & Master of Science
  Yale University
• Ph.D.,
  Yale University
• M.D.,
  Yale University School of Medicine
• , Medical Oncology Fellowship
  Dana-Farber Partners Cancer Care

Publications

• Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts.

  Manghi P, Bhosle A, Wang K, Marconi R, Selma-Royo M, Ricci L, Asnicar F, Golzato D, Ma W, Hang D, Thompson KN, Franzosa EA, Nabinejad A, Tamburini S, Rimm EB, Garrett WS, Sun Q, Chan AT, Valles-Colomer M, Arumugam M, Bermingham KM, Giordano F, Davies R, Hadjigeorgiou G, Wolf J, Strowig T, Berry SE, Huttenhower C, Spector TD, Segata N, Song M. Nat Microbiol 2024

• Chronic binge drinking-induced susceptibility to colonic inflammation is microbiome-dependent.

  Fonseca-Pereira D, Bae S, Michaud M, Glickman JN, Garrett WS. Gut Microbes 2024 Jan-Dec

• An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk.

  Wang K, Lo CH, Mehta RS, Nguyen LH, Wang Y, Ma W, Ugai T, Kawamura H, Ugai S, Takashima Y, Mima K, Arima K, Okadome K, Giannakis M, Sears CL, Meyerhardt JA, Ng K, Segata N, Izard J, Rimm EB, Garrett WS, Huttenhower C, Giovannucci EL, Chan AT, Ogino S, Song M. Gastroenterology 2024

• Interactions between diet and gut microbiota in cancer.

  Nakatsu G, Andreeva N, MacDonald MH, Garrett WS. Nat Microbiol 2024

• Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms.

  Ciorba MA, Konnikova L, Hirota SA, Lucchetta EM, Turner JR, Slavin A, Johnson K, Condray CD, Hong S, Cressall BK, Pizarro TT, Hurtado-Lorenzo A, Heller CA, Moss AC, Swantek JL, Garrett WS. Inflamm Bowel Dis 2024 May 23