Publications & News

Sarosiek Laboratory Publications

• Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance.
  Xingping Qin, Adam Presser, Lissah Johnson, Yusuke Matoba, Brendan Shay, Weiyi Xu, Jonathan Choiniere, Cameron Fraser, Filip Garbicz, Johan K.E. Spetz, Stacey Yu, Mary H.C. Florido, Francesca Picucci, Yang Yang, Ronny Drapkin, Sarah J. Hill, Daniel Ruben Carrasco, Joyce Liu, Ursula Matulonis, Joan Brugge, Bo Rueda, Daohong Zhou, Elizabeth Stover, Kristopher Sarosiek
  BioRxiv. 2025 June 26.
  


• LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers.
  Li C, Syed MU, Nimbalkar A, Shen Y, Vieira MD, Fraser C, Inde Z, Qin X, Ouyang J, Kreuzer J, Clark SE, Kelley G, Hensley EM, Morris R, Lazaro R, Belmonte B, Oh A, Walcott M, Nabel CS, Caenepeel S, Saiki AY, Rex K, Lipford JR, Heist RS, Lin JJ, Haas W, Kristopher Sarosiek, Hughes PE, Hata AN.
  Nature Communications. 2025 May 2;16(1):4112.
  


• A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma.
  Rendo V, Lee EQ, Bossi C, Khuu N, Rudek MA, Pal S, Azazmeh N, Rashid R, Lin JR, Cusick M, Reynolds ARN, Fassinou ACR, Ayoub G, Malinowski S, Lapinskas E, Pisano W, Jeang J, Stopka SA, Regan MS, Spetz J, Desai A, Lieberman F, Palanichamy K, Fisher JD, Pelton K, Huang RY, Kristopher Sarosiek, Nabors LB, Holdhoff M, Danda N, Strowd R, Desideri S, Walbert T, Ye X, Chakravarti A, Sorger PK, Santagata S, Agar NYR, Grossman SA, Alexander BM, Wen PY, Ligon KL, Beroukhim R.
  Science Translational Medicine. 2025 Feb 19;17(786):eadn6274.
  


• Author Correction: AI is a viable alternative to high throughput screening: a 318-target study.
  Atomwise AIMS Program.
  Scientific Reports. 2024 Sep 16;14(1):21579.
  


• Inflammation and mitophagy are mitochondrial checkpoints to aging.
  Emma Guilbaud, Kristopher Sarosiek, Lorenzo Galluzzi.
  Nature Communications. 2024 Apr 20;15(1):3375.
  


• AI is a viable alternative to high throughput screening: a 318-target study.
  Atomwise AIMS Program.
  Scientific Reports. 2024 Apr 2;14(1):7526.
  


• Functional genomic screens with death rate analyses reveal mechanisms of drug action.
  Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Kristopher Sarosiek, Guertin DA, Spinelli JB, Lee MJ.
  Nature Chemical Biology. 2024 Nov;20(11):1443-1452.
  


• Targeting Galectin 3 illuminates its contributions to the pathology of uterine serous carcinoma.
  Matoba Y, Zarrella DT, Pooladanda V, Azimi Mohammadabadi M, Kim E, Kumar S, Xu M, Qin X, Ray LJ, Devins KM, Kumar R, Kononenko A, Eisenhauer E, Veillard IE, Yamagami W, Hill SJ, Kristopher Sarosiek, Yeku OO, Spriggs DR, Rueda BR.
  British Journal of Cancer. 2024 May;130(9):1463-1476.
  


• In situ architecture of Opa1-dependent mitochondrial cristae remodeling.
  Fry MY, Navarro PP, Hakim P, Ananda VY, Qin X, Landoni JC, Rath S, Inde Z, Lugo CM, Luce BE, Ge Y, McDonald JL, Ali I, Ha LL, Kleinstiver BP, Chan DC, Kristopher Sarosiek, Chao LH.
  EMBO Journal. 2024 Feb;43(3):391-413.
  


• Role of intrinsic apoptosis in environmental exposure health outcomes.
  Johnson L, Kristopher Sarosiek.
  Trends in Molecular Medicine. 2024 Jan;30(1):56-73.
  


• Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level.
  Yamaguchi A, Maeshige N, Noguchi H, Yan J, Ma X, Uemura M, Su D, Kondo H, Kristopher Sarosiek, Fujino H.
  eLife. 2023 Dec 6;12:RP89512.
  


• Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification.
  Brown N, Rocchi P, Carmès L, Guthier R, Iyer M, Seban L, Morris T, Bennett S, Lavelle M, Penailillo J, Carrasco R, Williams C, Huynh E, Han Z, Kaza E, Doussineau T, Toprani SM, Qin X, Nagel ZD, Kristopher Sarosiek, Hagège A, Dufort S, Bort G, Lux F, Tillement O, Berbeco R.
  Theranostics. 2023 Aug 21;13(14):4711-4729.
  


• Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX.
  Singh R, Yu S, Osman M, Inde Z, Fraser C, Cleveland AH, Almanzar N, Lim CB, Joshi GN, Spetz J, Qin X, Toprani SM, Nagel Z, Hocking MC, Cormack RA, Yock TI, Miller JW, Yuan ZM, Gershon T, Kristopher Sarosiek.
  Cancer Research. 2023 Oct 13;83(20):3442-3461.
  


• Endogenous and imposed determinants of apoptotic vulnerabilities in cancer.
  Kristopher Sarosiek, Wood KC.
  Trends in Cancer. 2023 Feb;9(2):96-110.
  


• Apoptotic cell death in disease-Current understanding of the NCCD 2023.
  Vitale I, Pietrocola F, Guilbaud E, … Kristopher Sarosiek, et al.
  Cell Death & Differentiation. 2023 May;30(5):1097-1154.
  


• p53 controls choice between apoptotic and non-apoptotic death following DNA damage.
  Honeywell ME, Isidor MS, Harper NW, Fontana RE, Cruz-Gordillo P, Porto SA, Fraser CS, Kristopher Sarosiek, Guertin DA, Spinelli JB, Lee MJ.
  bioRxiv [Preprint]. 2023 May 16:2023.01.17.524444.
  


• In situ architecture of Opa1-dependent mitochondrial cristae remodeling.
  Fry MY, Navarro PP, Hakim P, Ananda VY, Qin X, Landoni JC, Rath S, Inde Z, Lugo CM, Luce BE, Ge Y, McDonald JL, Ali I, Ha LL, Kleinstiver BP, Chan DC, Kristopher Sarosiek, Chao LH.
  bioRxiv [Preprint]. 2023 Nov 9:2023.01.16.524176.
  


• Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization.
  Aguilar F, Yu S, Grant RA, Swanson S, Ghose D, Su BG, Kristopher Sarosiek, Keating AE.
  Structure. 2023 Mar 2;31(3):265-281.e7.
  


• Targeting TBK1 to overcome resistance to cancer immunotherapy.
  Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, Fu A, Ma X, Gwee J, Tiwari P, Du PP, Sindurakar P, Tian J, Mehta A, Schneider AM, Yizhak K, Sade-Feldman M, LaSalle T, Sharova T, Xie H, Liu S, Michaud WA, Saad-Beretta R, Yates KB, Iracheta-Vellve A, Spetz JKE, Qin X, Kristopher Sarosiek, Zhang G, Kim JW, Su MY, … Jenkins RW.
  Nature. 2023 Mar;615(7950):158-167.
  


• Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex.
  McNamara MC, Hosios AM, Torrence ME, Zhao T, Fraser C, Wilkinson M, Kwiatkowski DJ, Henske EP, Wu CL, Kristopher Sarosiek, Valvezan AJ, Manning BD.
  iScience. 2022 Oct 28;25(11):105458.
  


• Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities.
  Spetz JKE, Florido MHC, Fraser CS, Qin X, Choiniere J, Yu SJ, Singh R, Friesen M, Rubin LL, Salem JE, Moslehi JJ, Kristopher Sarosiek.
  Science Advances. 2022 Nov 11;8(45):eabn6579.
  


• Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics.
  Fraser CS, Spetz JKE, Qin X, Presser A, Choiniere J, Li C, Yu S, Blevins F, Hata AN, Miller JW, Bradshaw GA, Kalocsay M, Sanchorawala V, Sarosiek S, Kristopher Sarosiek.
  Nature Communications. 2022 Oct 2;13(1):5789.
  


• Small molecule SJ572946 activates BAK to initiate apoptosis.
  Sekar G, Singh G, Qin X, Guibao CD, Schwam B, Inde Z, Grace CR, Zhang W, Slavish PJ, Lin W, Chen T, Lee RE, Rankovic Z, Kristopher Sarosiek, Moldoveanu T.
  iScience. 2022 Sep 6;25(10):105064.
  


• A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer.
  Grubb T, Maganti S, Krill-Burger JM, Fraser C, Stransky L, Radivoyevitch T, Kristopher Sarosiek, Vazquez F, Kaelin WG, Chakraborty AA.
  Clinical Cancer Research. 2022 Nov 1;28(21):4689-4701.
  


• Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.
  Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Kristopher Sarosiek.
  Science Advances. 2021 Aug 18;7(34):eabf8609.
  


• Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.
  Daniels VW, Zoeller JJ, van Gastel N, McQueeney KE, Parvin S, Potter DS, Fell GG, Ferreira VG, Yilma B, Gupta R, Spetz J, Bhola PD, Endress JE, Harris IS, Carrilho E, Kristopher Sarosiek, Scadden DT, Brugge JS, Letai A.
  Science Signaling. 2021 Jun 8;14(686):eabc7405.
  


• Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity.
  Inde Z, Yapp C, Joshi GN, Spetz J, Fraser C, Deskin B, Ghelfi E, Sodhi C, Hackam DJ, Kobzik L, Croker BA, Brownfield D, Jia H, Kristopher Sarosiek.
  bioRxiv [Preprint]. 2020 Sep 13:2020.09.13.276923.
  


• Short-term exposure to ambient particle gamma radioactivity is associated with increased risk for all-cause non-accidental and cardiovascular mortality.
  Huang S, Xiong J, Vieira CLZ, Blomberg AJ, Gold DR, Coull BA, Kristopher Sarosiek, Schwartz JD, Wolfson JM, Li J, Koutrakis P.
  Science of the Total Environment. 2020 Jun 15;721:137793.
  


• HSF1 phase transition mediates stress adaptation and cell fate decisions.
  Gaglia G, Rashid R, Yapp C, Joshi GN, Li CG, Lindquist SL, Kristopher Sarosiek, Whitesell L, Sorger PK, Santagata S.
  Nature Cell Biology. 2020 Feb;22(2):151-158.
  


• Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity.
  Rubio L, Pyrgiotakis G, Beltran-Huarac J, Zhang Y, Gaurav J, Deloid G, Spyrogianni A, Kristopher Sarosiek, Bello D, Demokritou P.
  Particle and Fibre Toxicology. 2019 Oct 29;16(1):40.
  


• Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer.
  Stover EH, Baco MB, Cohen O, Li YY, Christie EL, Bagul M, Goodale A, Lee Y, Pantel S, Rees MG, Wei G, Presser AG, Gelbard MK, Zhang W, Zervantonakis IK, Bhola PD, Ryan J, Guerriero JL, Montero J, Liang FJ, Cherniack AD, Piccioni F, Matulonis UA, Bowtell DDL, Kristopher Sarosiek, Letai A, Garraway LA, Johannessen CM, Meyerson M.
  Molecular Cancer Research. 2019 Nov;17(11):2281-2293.
  


• Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents.
  Lossos C, Liu Y, Kolb KE, Christie AL, Van Scoyk A, Prakadan SM, Shigemori K, Stevenson KE, Morrow S, Plana OD, Fraser C, Jones KL, Liu H, Pallasch CP, Modiste R, Nguyen QD, Craig JW, Morgan EA, Vega F, Aster JC, Kristopher Sarosiek, Shalek AK, Hemann MT, Weinstock DM.
  Cancer Discovery. 2019 Jul;9(7):944-961.
  


• Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.
  Singh R, Letai A, Kristopher Sarosiek.
  Nature Reviews Molecular Cell Biology. 2019 Mar;20(3):175-193.
  


• T Cells and Regulated Cell Death: Kill or Be Killed.
  Spetz J, Presser AG, Kristopher Sarosiek.
  International Review of Cell and Molecular Biology. 2019;342:27-71.
  


• BH3 Profiling: A Functional Assay to Measure Apoptotic Priming and Dependencies.
  Fraser C, Ryan J, Kristopher Sarosiek.
  Methods in Molecular Biology. 2019;1877:61-76.
  


• Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer.
  Nangia V, Siddiqui FM, Caenepeel S, Timonina D, Bilton SJ, Phan N, Gomez-Caraballo M, Archibald HL, Li C, Fraser C, Rigas D, Vajda K, Ferris LA, Lanuti M, Wright CD, Raskin KA, Cahill DP, Shin JH, Keyes C, Sequist LV, Piotrowska Z, Farago AF, Azzoli CG, Gainor JF, Kristopher Sarosiek, Brown SP, Coxon A, Benes CH, Hughes PE, Hata AN.
  Cancer Discovery. 2018 Dec;8(12):1598-1613.
  


• Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
  McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Kristopher Sarosiek, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr.
  Cell. 2018 Sep 20;175(1):101-116.e25.
  


• Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment.
  Spetz J, Moslehi J, Kristopher Sarosiek.
  Current Treatment Options in Cardiovascular Medicine. 2018 Mar 20;20(4):31.
  


• Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage.
  Gutierrez-Martinez P, Hogdal L, Nagai M, Kruta M, Singh R, Kristopher Sarosiek, Nussenzweig A, Beerman I, Letai A, Rossi DJ.
  Nature Cell Biology. 2018 Apr;20(4):413-421.
  


• BCL-XL directly modulates RAS signalling to favour cancer cell stemness.
  Carné Trécesson S, Souazé F, Basseville A, Bernard AC, Pécot J, Lopez J, Bessou M, Kristopher Sarosiek, Letai A, Barillé-Nion S, Valo I, Coqueret O, Guette C, Campone M, Gautier F, Juin PP.
  Nature Communications. 2017 Oct 24;8(1):1123.
  


• Epigenetics make transient states of cancer therapy resistance permanent.
  Kristopher Sarosiek.
  Science Translational Medicine. 2017 Jun 28;9(396):eaan6729.
  


• Chemotherapy-treated cells go up in flames.
  Kristopher Sarosiek.
  Science Translational Medicine. 2017 May 17;9(390):eaan4289.
  


• Double trouble for CML.
  Kristopher Sarosiek.
  Science Translational Medicine. 2017 Apr 5;9(384):e2773.
  


• Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis.
  Gunda V, Kristopher Sarosiek, Brauner E, Kim YS, Amin S, Zhou Z, Letai A, Parangi S.
  Cancer Letters. 2017 Jun 1;395:1-10.
  


• Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.
  Kristopher Sarosiek, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A.
  Cancer Cell. 2017 Jan 9;31(1):142-156.
  


• Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance.
  Pécot J, Maillet L, Le Pen J, Vuillier C, Trécesson SC, Fétiveau A, Kristopher Sarosiek, Bock FJ, Braun F, Letai A, Tait SWG, Gautier F, Juin PP.
  Cell Reports. 2016 Dec 20;17(12):3347-3358.
  


• CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.
  Johnson SF, Cruz C, Greifenberg AK, Dust S, Stover DG, Chi D, Primack B, Cao S, Bernhardy AJ, Coulson R, Lazaro JB, Kochupurakkal B, Sun H, Unitt C, Moreau LA, Kristopher Sarosiek, Scaltriti M, Juric D, Baselga J, Richardson AL, Rodig SJ, D’Andrea AD, Balmaña J, Johnson N, Geyer M, Serra V, Lim E, Shapiro GI.
  Cell Reports. 2016 Nov 22;17(9):2367-2381.
  


• Interleukin 21 – its potential role in the therapy of B-cell lymphomas.
  Bhatt S, Kristopher Sarosiek, Lossos IS.
  Leukemia & Lymphoma. 2017 Jan;58(1):17-29.
  


• Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition.
  Burger JA, Landau DA, Taylor-Weiner A, Bozic I, Zhang H, Kristopher Sarosiek, Wang L, Stewart C, Fan J, Hoellenriegel J, Sivina M, Dubuc AM, Fraser C, Han Y, Li S, Livak KJ, Zou L, Wan Y, Konoplev S, Sougnez C, Brown JR, Abruzzo LV, Carter SL, Keating MJ, Davids MS, Wierda WG, Cibulskis K, Zenz T, Werner L, Dal Cin P, Kharchencko P, Neuberg D, Kantarjian H, Lander E, Gabriel S, O’Brien S, Letai A, Weitz DA, Nowak MA, Getz G, Wu CJ.
  Nature Communications. 2016 May 20;7:11589.
  


• Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics – recent successes, current challenges and future promise.
  Kristopher Sarosiek, Letai A.
  The FEBS Journal. 2016 Oct;283(19):3523-3533.
  


• Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
  Bhatt S, Matthews J, Parvin S, Kristopher Sarosiek, Zhao D, Jiang X, Isik E, Letai A, Lossos IS.
  Blood. 2015 Sep 24;126(13):1555-64.
  


• Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
  Montero J, Kristopher Sarosiek, DeAngelo JD, Maertens O, Ryan J, Ercan D, Piao H, Horowitz NS, Berkowitz RS, Matulonis U, Jänne PA, Amrein PC, Cichowski K, Drapkin R, Letai A.
  Cell. 2015 Feb 26;160(5):977-989.
  


• RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
  Winter PS, Kristopher Sarosiek, Lin KH, Meggendorfer M, Schnittger S, Letai A, Wood KC.
  Science Signaling. 2014 Dec 23;7(357):ra122.
  


• Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
  Hata AN, Yeo A, Faber AC, Lifshits E, Chen Z, Cheng KA, Walton Z, Kristopher Sarosiek, Letai A, Heist RS, Mino-Kenudson M, Wong KK, Engelman JA.
  Cancer Research. 2014 Jun 1;74(11):3146-56.
  


• Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.
  Johnson N, Johnson SF, Yao W, Li YC, Choi YE, Bernhardy AJ, Wang Y, Capelletti M, Kristopher Sarosiek, Moreau LA, Chowdhury D, Wickramanayake A, Harrell MI, Liu JF, D’Andrea AD, Miron A, Swisher EM, Shapiro GI.
  Proceedings of the National Academy of Sciences. 2013 Oct 15;110(42):17041-6.
  


• BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response.
  Kristopher Sarosiek, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, Letai A.
  Molecular Cell. 2013 Sep 26;51(6):751-65.
  


• Mitochondria: gatekeepers of response to chemotherapy.
  Kristopher Sarosiek, Ni Chonghaile T, Letai A.
  Trends in Cell Biology. 2013 Dec;23(12):612-9.
  


• Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.
  Ni Chonghaile T, Kristopher Sarosiek, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, Mitsiades CS, Matulonis UA, Drapkin R, Stone R, Deangelo DJ, McConkey DJ, Sallan SE, Silverman L, Hirsch MS, Carrasco DR, Letai A.
  Science. 2011 Nov 25;334(6059):1129-33.
  


• HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.
  Jiang X, Lu X, McNamara G, Liu X, Cubedo E, Kristopher Sarosiek, Sánchez-García I, Helfman DM, Lossos IS.
  Blood. 2010 Dec 9;116(24):5217-27.
  


• Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma.
  Kristopher Sarosiek, Cavallin LE, Bhatt S, Toomey NL, Natkunam Y, Blasini W, Gentles AJ, Ramos JC, Mesri EA, Lossos IS.
  Proceedings of the National Academy of Sciences. 2010 Jul 20;107(29):13069-74.
  


• Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas.
  Kristopher Sarosiek, Malumbres R, Nechushtan H, Gentles AJ, Avisar E, Lossos IS.
  Blood. 2010 Jan 21;115(3):570-80.
  


• Interleukin-4 distinctively modifies responses of germinal centre-like and activated B-cell-like diffuse large B-cell lymphomas to immuno-chemotherapy.
  Kristopher Sarosiek, Nechushtan H, Lu X, Rosenblatt JD, Lossos IS.
  British Journal of Haematology. 2009 Nov;147(3):308-18.
  


• Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas.
  Malumbres R, Kristopher Sarosiek, Cubedo E, Ruiz JW, Jiang X, Gascoyne RD, Tibshirani R, Lossos IS.
  Blood. 2009 Apr 16;113(16):3754-64.
  


• PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
  Lu X, Malumbres R, Shields B, Jiang X, Kristopher Sarosiek, Natkunam Y, Tiganis T, Lossos IS.
  Blood. 2008 Nov 15;112(10):4098-108.
  


• T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6.
  Lu X, Chen J, Sasmono RT, Hsi ED, Kristopher Sarosiek, Tiganis T, Lossos IS.
  Molecular and Cellular Biology. 2007 Mar;27(6):2166-79.