2022 PQG Conference: Emerging challenges and opportunities in gene editing

Thursday, November 3, 2022

9:00-9:15 Opening Remarks, Stellar Abstract Awards

SESSION I: THERAPEUTICS
Moderators: Xihong Lin and Kyle Vogan

* last 5 minutes of all session talks reserved for questions and discussion

9:15-10:05 
Sek Kathiresan | KEYNOTE SPEAKER
Verve Therapeutics
From reading the genome for risk to rewriting it for cardiovascular health

10:05-10:35
Daniel Bauer | Boston Children’s Hospital, DFCI, HMS
Gene editing for blood disorders

10:35-10:50
Gabriele Casirati | Abstract Winner Platform Talk I
Epitope Engineered Hematopoietic Stem and Progenitor Cells to Enable CAR-T Cell Immunotherapy for Acute Myeloid Leukemia

10:50-11:05 BREAK

11:05-11:35
Laura Sepp-Lorenzino | Intellia Therapeutics
Clinical advances in CRISPR Cas9 Therapeutics: In Vivo and Cell Therapy Applications

11:35-12:05
Nicole Gaudelli | Beam Therapeutics
Directed evolution and engineering of CBE-T: next-generation cytosine base editors utilizing TadA

12:05 – 2:30
Gathertown / POSTER SESSION

Friday, November 4, 2022

SESSION II: DISCOVERY APPLICATIONS
Moderators: Brittney Adamson and Luca Pinello

9:00-9:50
Bev Davidson | KEYNOTE SPEAKER
Perelman School of Medicine, University of Pennsylvania / Children’s Hospital of Philadelphia
Editing for Huntington’s Disease

9:50-10:20
Christoph Bock | Research Center for Molecular Medicine of the Austrian Academy of Sciences
CROP-seq and scifi-RNA-seq: Single-cell CRISPR sequencing at scale

10:20-10:35 BREAK

10:35-10:50
Wancen Mu | Abstract Winner Platform Talk
 II
Machine learning based methods for predicting guide RNA effects in CRISPR epigenomic experiments

10:50-11:20
Kristin Knouse | Koch Institute, MIT
Delivering insights into organ homeostasis and regeneration through in vivo genome-wide screens

11:20-11:50
Mathew Garnett | Wellcome Sanger Institute
Functional Genomics for Cancer Drug Discovery

11:50-1:15 Gathertown

SESSION III: CHALLENGES AND TECHNOLOGIES
Moderators: John Doench, Ben Kleinstiver, Alexis Komor

1:15-2:05
David Liu | KEYNOTE SPEAKER
Broad Institute / Harvard University
Base Editing and Prime Editing: Precise Gene Correction Without Double-Strand DNA Breaks

2:05-2:35
Samuel Sternberg | Columbia University
Discovery and development of CRISPR-associated transposases for RNA-guided DNA integration

2:35-3:05
Cecilia Cotto-Ramusino | Tessera / Flagship Pioneering
Harnessing mobile genetic elements to write DNA sequences with RNA

3:05-3:20 BREAK

3:20-3:35
Nicolas Mathis | Abstract Winner Platform Talk
 III
Predicting prime editing efficiency and product purity by deep learning

3:35-4:05
James Dahlman | Georgia Tech and Emory University
Delivering RNA outside the liver by testing thousands of nanoparticles vivo

4:05 – 4:15
Closing remarks