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Allergy, Climate, and Exposomics Lab

The Allergy, Climate, and Exposomics (ACE) Lab studies how environmental exposures impact our immune system and our overall health. We research these topics through the lens of climate change, the number one threat to global public health. 

Location

651 Huntington Avenue
FXB Building, Room 101
Boston, MA 02115

Baby eating outside on picnic blanket

SEAL (Stopping Eczema and ALlergy) Study: Prevent allergy by enhancing the skin barrier

About the SEAL Study

Funded by U01 AI147462 

Food allergy is an epidemic among children in the U.S., U.K., and other countries. By reducing dry skin, the duration and severity of eczema and preventing eczema exacerbations with skin barrier protection and anti-inflammatory creams, we aim to significantly reduce the incidence of food allergy.

Publications

Zhou X, Simonin EM, Jung YS, Galli SJ, Nadeau KC. Role of allergen immunotherapy and biologics in allergic diseases. Curr Opin Immunol. 2024 Oct 1;91:102494. doi: 10.1016/j.coi.2024.102494. Epub ahead of print. PMID: 39357079.

Choma EF, Robinson LA, Nadeau KC. Adopting electric school buses in the United States: Health and climate benefits. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2320338121. doi: 10.1073/pnas.2320338121. Epub 2024 May 20. PMID: 38768355; PMCID: PMC11145267.

Zhou X, Sampath V, Nadeau KC. Effect of air pollution on asthma. Ann Allergy Asthma Immunol. 2024 Apr;132(4):426-432. doi: 10.1016/j.anai.2024.01.017. Epub 2024 Jan 20. PMID: 38253122; PMCID: PMC10990824.

Akdis CA, Akdis M, Boyd SD, Sampath V, Galli SJ, Nadeau KC. Allergy: Mechanistic insights into new methods of prevention and therapy. Sci Transl Med. 2023 Jan 18;15(679):eadd2563. doi: 10.1126/scitranslmed.add2563. Epub 2023 Jan 18. PMID: 36652536.

Ogulur I, Yazici D, Pat Y, Bingöl EN, Babayev H, Ardicli S, Heider A, Rückert B, Sampath V, Dhir R, Akdis M, Nadeau K, Akdis CA. Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80. Allergy. 2023 Sep;78(9):2441-2455. doi: 10.1111/all.15825. Epub 2023 Aug 2. PMID: 37530764.

Seastedt H, Nadeau K. Factors by which global warming worsens allergic disease. Ann Allergy Asthma Immunol. 2023 Dec;131(6):694-702. doi: 10.1016/j.anai.2023.08.610. Epub 2023 Sep 7. PMID: 37689112; PMCID: PMC10873081.

Pat Y, Ogulur I, Yazici D, Mitamura Y, Cevhertas L, Küçükkase OC, Mesisser SS, Akdis M, Nadeau K, Akdis CA. Effect of altered human exposome on the skin and mucosal epithelial barrier integrity. Tissue Barriers. 2023 Oct 2;11(4):2133877. doi: 10.1080/21688370.2022.2133877. Epub 2022 Oct 19. PMID: 36262078; PMCID: PMC10606824.

Ogulur I, Pat Y, Aydin T, Yazici D, Rückert B, Peng Y, Kim J, Radzikowska U, Westermann P, Sokolowska M, Dhir R, Akdis M, Nadeau K, Akdis CA. Gut epithelial barrier damage caused by dishwasher detergents and rinse aids. J Allergy Clin Immunol. 2023 Feb;151(2):469-484. doi: 10.1016/j.jaci.2022.10.020. Epub 2022 Dec 1. PMID: 36464527.

Celebi Sozener Z, Ozdel Ozturk B, Cerci P, Turk M, Gorgulu Akin B, Akdis M, Altiner S, Ozbey U, Ogulur I, Mitamura Y, Yilmaz I, Nadeau K, Ozdemir C, Mungan D, Akdis CA. Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease. Allergy. 2022 May;77(5):1418-1449. doi: 10.1111/all.15240. Epub 2022 Feb 16. PMID: 35108405; PMCID: PMC9306534.

Leung DYM, Elias PM, Nadeau KC, Berdyshev E. Olive oil is for eating and not skin moisturization. J Allergy Clin Immunol. 2021 Aug;148(2):652. doi: 10.1016/j.jaci.2021.04.037. Epub 2021 Jun 16. PMID: 34144820.

Manohar M, Dunham D, Gupta S, Yan Z, Zhang W, Minnicozzi S, Kirkey M, Bunning B, Roy Chowdhury R, Galli SJ, Boyd SD, Kost LE, Chinthrajah RS, Desai M, Oettgen HC, Maecker HT, Yu W, DeKruyff RH, Andorf S, Nadeau KC. Immune changes beyond Th2 pathways during rapid multifood immunotherapy enabled with omalizumab. Allergy. 2021 Sep;76(9):2809-2826. doi: 10.1111/all.14833. Epub 2021 May 29. PMID: 33782956; PMCID: PMC8609920.

Movassagh H, Halchenko Y, Sampath V, Nygaard UC, Jackson B, Robbins D, Li Z, Nadeau KC, Karagas MR. Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures. Environ Res. 2021 Oct;201:111385. doi: 10.1016/j.envres.2021.111385. Epub 2021 Jun 12. PMID: 34129869; PMCID: PMC8478717.

Warren CM, Snow TT, Lee AS, Shah MM, Heider A, Blomkalns A, Betts B, Buzzanco AS, Gonzalez J, Chinthrajah RS, Do E, Chang I, Dunham D, Lee G, O’Hara R, Park H, Shamji MH, Schilling L, Sindher SB, Sisodiya D, Smith E, Tsai M, Galli SJ, Akdis C, Nadeau KC. Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System. JAMA Netw Open. 2021 Sep 1;4(9):e2125524. doi: 10.1001/jamanetworkopen.2021.25524. PMID: 34533570; PMCID: PMC8449279.

Yu W, Zhou X, Lyu SC, Davis MM, Nadeau KC. Regulation of peanut-specific CD8+ T cells from nonallergic individuals. J Allergy Clin Immunol. 2021 Jan;147(1):385-387.e1. doi: 10.1016/j.jaci.2020.07.032. Epub 2020 Aug 21. PMID: 32835695; PMCID: PMC7855141.

Andorf S, Bunning B, Tupa D, Cao S, Long AJ, Borres MP, Galli SJ, Chinthrajah RS, Nadeau KC. Trends in egg specific immunoglobulin levels during natural tolerance and oral immunotherapy. Allergy. 2020 Jun;75(6):1454-1456. doi: 10.1111/all.14107. Epub 2019 Dec 3. PMID: 31724180; PMCID: PMC7220838.

Brough HA, Nadeau KC, Sindher SB, Alkotob SS, Chan S, Bahnson HT, Leung DYM, Lack G. Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented? Allergy. 2020 Sep;75(9):2185-2205. doi: 10.1111/all.14304. Epub 2020 May 18. PMID: 32249942; PMCID: PMC7494573.

Celebi Sözener Z, Cevhertas L, Nadeau K, Akdis M, Akdis CA. Environmental factors in epithelial barrier dysfunction. J Allergy Clin Immunol. 2020 Jun;145(6):1517-1528. doi: 10.1016/j.jaci.2020.04.024. PMID: 32507229.

Dhondalay GKR, Bunning B, Bauer RN, Barnathan ES, Maniscalco C, Baribaud F, Nadeau KC, Andorf S. Transcriptomic and methylomic features in asthmatic and nonasthmatic twins. Allergy. 2020 Apr;75(4):989-992. doi: 10.1111/all.14128. Epub 2020 Jan 21. PMID: 31758558; PMCID: PMC7176546.

Hoh RA, Joshi SA, Lee JY, Martin BA, Varma S, Kwok S, Nielsen SCA, Nejad P, Haraguchi E, Dixit PS, Shutthanandan SV, Roskin KM, Zhang W, Tupa D, Bunning BJ, Manohar M, Tibshirani R, Fernandez-Becker NQ, Kambham N, West RB, Hamilton RG, Tsai M, Galli SJ, Chinthrajah RS, Nadeau KC, Boyd SD. Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy. Sci Immunol. 2020 Mar 6;5(45):eaay4209. doi: 10.1126/sciimmunol.aay4209. PMID: 32139586; PMCID: PMC7691169.

Luce S, Chinthrajah S, Lyu SC, Nadeau KC, Mascarell L. Th2A and Th17 cell frequencies and regulatory markers as follow-up biomarker candidates for successful multifood oral immunotherapy. Allergy. 2020 Jun;75(6):1513-1516. doi: 10.1111/all.14180. Epub 2020 Jan 31. PMID: 31930521; PMCID: PMC8164780.

Sindher S, Alkotob SS, Shojinaga MN, Brough HA, Bahnson HT, Chan S, Lack G, Leung DYM, Nadeau KC. Pilot study measuring transepidermal water loss (TEWL) in children suggests trilipid cream is more effective than a paraffin-based emollient. Allergy. 2020 Oct;75(10):2662-2664. doi: 10.1111/all.14275. Epub 2020 Apr 12. PMID: 32176320; PMCID: PMC7951178.

Sindher S, Alkotob SS, Shojinaga MN, Hamilton R, Chan S, Cao S, Bahnson HT, Brough HA, Lack G, Leung DYM, Nadeau KC. Increases in plasma IgG4/IgE with trilipid vs paraffin/petrolatum-based emollients for dry skin/eczema. Pediatr Allergy Immunol. 2020 Aug;31(6):699-703. doi: 10.1111/pai.13253. Epub 2020 May 6. PMID: 32372469; PMCID: PMC8078833.