Le Pen Lab
Our lab focuses on innate immunity to RNA viruses. The genomes of humans and other animals harbor genes that have naturally evolved to combat viral infections and promote health. Our goal is to identify these antiviral strategies shaped by nature and uncover their mechanisms of action.
Location
651 Huntington Avenue,
Building FXB, Room 205
Boston, MA 02115
Publications
Featured Publications
- A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist
- The antiviral state of the cell: lessons from SARS-CoV-2
- Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
- Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
- Terminal uridylyltransferases target RNA viruses as part of the innate immune system
- A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity