BayesMendel Lab
The BayesMendel Lab develops sophisticated statistical models and software that identify individuals with elevated cancer risk due to inherited genetic factors, providing them with accurate risk assessments, and better access to detection and prevention strategies.
450 Brookline Ave
Boston, MA 02215
Our Software
Our risk prediction software help patients, clinicians, and researchers better assess cancer risks and implement effective prevention strategies.
BayesMendel is an R package for Mendelian risk prediction. It includes implementation of the BRCAPRO, MMRpro, PancPRO and MelaPRO models, as well as functionality to adapt BRCAPRO, MMRpro, PancPRO and MelaPRO to specific populations and to develop new Mendelian risk prediction models for other syndromes.
Fam3PRO is a flexible multi-gene multi-cancer R package for Mendelian risk prediction.
ASK2ME is a clinician-facing decision support tool for individuals who have undergone multi-gene panel testing, developed in collaboration with Dr. Kevin Hughes at Massachusetts General Hospital.
ASK2ME provides a calculator to determine risk and the existing management guidelines for most of these genes (with more to follow). We have chosen the best papers we can find on ATM, BARD1, BRCA1, BRCA2, BRIP1, BMPR1A, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, STK11, TP53, and converted their general risk estimates to patient specific estimates, and collated the major management guidelines to simplify determining a management strategy.
MyLynch is a patient-facing tool to help people with Lynch Syndrome (LS) understand how LS can increase the risk of different cancers and show them what they can do to lower their risks.
Our software is available for clinical use through various third-party clinical software.
If you are planning on embedding the software into your own tool or if you are pursuing commercial software development that incorporates our software, please contact Giovanni Parmigiani or Danielle Braun for information on licensing.
If you would like to collaborate on research projects using the BayesMendel or Fam3PRO R packages please contact Giovanni Parmigiani or Danielle Braun for more information.