Nowcasting approaches enhance the utility of reportable disease data for trend monitoring by correcting for delays, but implementation details affect accuracy.

There is no agreed methodology for pharmacometric assessment of candidate antiviral drugs in COVID-19. The most widely used measure of virological response in clinical trials so far is the time to viral clearance assessed by qPCR of viral nucleic acid in eluates from serial nasopharyngeal swabs. We posited that the rate of viral clearance would have better discriminatory value. Using a pharmacodynamic model fit to individual SARS-CoV-2 virus clearance data from 46 uncomplicated COVID-19 infections in a cohort of prospectively followed adults, we simulated qPCR viral load data to compare type 2 errors when using time to clearance and rate of clearance under varying antiviral effects, sample sizes, sampling frequencies and durations of follow-up.

Gastric cancer (GC) is a significant global health problem, with Helicobacter pylori infection estimated to be responsible for 89% of non-cardiac GC cases, or 78% of all GC cases. The International Agency for Research on Cancer has called for Helicobacter pylori test-and-treat strategies in countries with high rates of GC. However, for countries with low rates of GC, such as most Western countries, the balance between benefits, harms and costs of screening is less clear-cut. GC is a disease with a well-characterized precancerous process, providing the basis for primary and secondary prevention efforts. However, rigorous data assessing the impact of such interventions in Western countries are lacking. In the absence of clinical trials, modelling offers a unique approach to evaluate the potential impact of various screening and surveillance interventions. In this paper, we provide an overview of modelling studies evaluating the cost-effectiveness of GC screening and surveillance in Western countries.

In today’s era of medical advancement, various modalities of treatment options and dressing materials are available for burn wound management. Bilaminar dermal regeneration template is doubtful in developing countries because of its high cost availability and affordability.

Flexion contracture of finger is a major cause of disability in postburn patients. Various methods have been described to cover the resultant defect after surgical release of finger flexion contracture. Local flaps are used when there is sufficient tissue available on lateral sides of the finger to recruit into the defect. Keystone flap can be designed on volar aspect of finger to cover the post contracture release defect. Use of local flap reduces need of skin graft and donor site morbidity. Here we discuss a case of postburn finger flexion contracture release using type-3 keystone flap. Postoperative results are satisfactory. Various pros and cons of the technique are discussed. Keystone flap is a new addition to the armamentarium of plastic surgeons for release of postburn flexion contracture of fingers.

Peanut-specific CD8 T cells in nonallergic individuals are not deleted, but have an expansion block that can be released by impairing regulatory T cell associated signaling pathways.

Risk of tuberculosis (TB) declines over time since Mycobacterium tuberculosis infection, but progression to clinical disease is still possible decades later. In the United States, most TB cases result from the progression of latent TB infection acquired over 2 years ago.

One of the measures for the successful take of a skin graft is the prevention of friction, especially in cases of pressure ulcers in patients with head injury leading to altered sensorium. With existing measures such as the use of a pressure-relieving bed, frequent change of position, etc graft loss is common. Some additional measures are required. This study highlights the role of a donut-shaped ring dressing to protect the skin graft from friction.

Skin grafting is the transplantation of skin, a routinely performed procedure to cover the loss of skin. Skin is the largest organ of the body, which falls short of availability in extensive injuries, especially burns. In such a situation, pixel grafting, a novel expansion technique helps to cover a large area with less skin harvest. The objective of the study was to test fast, minimally invasive, easy to use minced split-thickness skin graft to cover large wounds and to reflect on the advantages of pixel graft. It is a pilot study of patients admitted with severe burns. We conclude that with this technique of pixel or minced grafting, large areas can be grafted with minimal donor-site requirement, and the techniques of preparation provide adequate size graft for pixel grafting.