Susan Redline

Biography

I direct the Program in Sleep Medicine Epidemiology at BWH. Our goals are to conduct rigorous and population-based research to: elucidate the role of genetics, early life developmental factors, and environmental exposures on sleep health; identify how social and environmental factors shape sleep health disparities which in turn drive chronic health disparities; and identify the role of sleep interventions in improving health, including cardiovascular, metabolic, and cognitive disorders.

Within the Program, we support the following Resources:

The BWH Sleep Reading Center (www.bostonsleep.org), an international core laboratory that provides leadership in the design and implementation of sleep data collection for numerous clinical trials and cohort studies. It spearheaded efforts at establishing rigorous quality control procedures for multi-site sleep research and for integrating advanced signal processing analytics into large scale-epidemiological datasets to provide quantitative biomarkers of sleep and sleep disorders.

The National Sleep Research Resource (NSRR; www.sleepdata.org), a NHLBI-data and tool repository and community engagement resource that shares large quantities of polysomnography, actigraphy and other data coupled with tools to structure, harmonize, visualize and analyze sleep data.

The Sleep Apnea Patient-Centered Outcomes Network (MyApnea; www.myapnea.org), a web-based portal to promote sleep apnea patient support and patient engagement in research.

I am the recipient of a NHLBI Outstanding Investigator Award (R35) that supports a research and training program, Phenotypic and Genomic Signatures For Sleep Apnea. This program brings together trainees and experts in epidemiology, genetic and sleep/respiratory physiology to identify biomarkers and molecular mechanisms for sleep apnea risk, models interactions between sleep disorders and genetic risk factors (G*E), and attempts to resolve the heterogeneity in sleep apnea that predicts differences in outcomes and treatment response.

I co-direct the following multi-center clinical trials:
Pediatric Adenotonsillectomy Trial (PATS; patstrial.org)
Impact of Low Flow Oxygen on Hospital Admissions and Mortality in Heart Failure and Central Sleep Apnea (LOFT-HF; lofthf.study).

I co-lead a cohort study examining the impact of the home environment on sleep disorders among children in low income urban neighborhoods. (Environmental Assessment of Sleep in Youth).

Education and Training

• BA, Six Year Medical Honors Program
  Boston University
• MD, Medicine
  Boston University School of Medicine
• MPH, Respiratory Epidemiology
  Harvard School Of Public Health

Awards and Honors

• William C Dement Scientific Achievement Award, 2017
  American Academy of Sleep Medicine
• Scientific Recognition Award, 2012
  American Thoracic Society
• Association of American Physicians, 2008
• Sleep In Infancy and Childhood Award, 2008
  Annenberg
• Spotlight on Women's Scholarship, 2007
  Case Western Reserve University

Publications

• Sleep apnea physiological burdens and markers of white matter injury: the Multi-Ethnic Study of Atherosclerosis.

  Hajipour M, Hu WH, Esmaeili N, Sands S, Wellman A, Kwon Y, Labarca G, Nasrallah IM, Bryan RN, Strollo PJ, Heckbert SR, Redline S, Ayas NT, Azarbarzin A. J Clin Sleep Med 2024 Oct 22

• Associations of seasonally available global positioning systems-derived walkability and objectively measured sleep in the Nurses' Health Study 3 Mobile Health Substudy.

  Hu CR, Wilt GE, Roscoe C, Iyer HS, Kessler WH, Laden F, Chavarro JE, Coull B, Redline S, James P, Hart JE. Environ Epidemiol 2024

• Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height.

  Hawkes G, Beaumont RN, Li Z, Mandla R, Li X, Albert CM, Arnett DK, Ashley-Koch AE, Ashrani AA, Barnes KC, Boerwinkle E, Brody JA, Carson AP, Chami N, Chen YI, Chung MK, Curran JE, Darbar D, Ellinor PT, Fornage M, Gordeuk VR, Guo X, He J, Hwu CM, Kalyani RR, Kaplan R, Kardia SLR, Kooperberg C, Loos RJF, Lubitz SA, Minster RL, Naseri T, Viali S, Mitchell BD, Murabito JM, Palmer ND, Psaty BM, Redline S, Shoemaker MB, Silverman EK, Telen MJ, Weiss ST, Yanek LR, Zhou H, Liu CT, North KE, Justice AE, Locke JM, Owens N, Murray A, Patel K, Frayling TM, Wright CF, Wood AR, Lin X, Manning A, Weedon MN. Nat Commun 2024 Oct 03

• Weight Gain After Adenotonsillectomy in Children With Mild Obstructive Sleep-Disordered Breathing: Exploratory Analysis of the PATS Randomized Clinical Trial.

  Kirkham EM, Ishman S, Baldassari CM, Mitchell RB, Naqvi SK, Tapia IE, Elden LM, Hassan F, Ibrahim S, Ross K, Cen M, Wang R, Redline S, Chervin RD. JAMA Otolaryngol Head Neck Surg 2024 Oct 01

• 24-Hour Activity Composition is Associated with Lower Fall and Fracture Risk in Older Men.

  Roe LS, Strotmeyer ES, Cawthon PM, Glynn NW, Ma Y, Ancoli-Israel S, Ensrud K, Redline S, Stone KL, Gabriel KP, Cauley JA. J Bone Miner Res 2024 Sep 30