Tamar Sofer

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Biography

I am a biostatistical researcher focusing on genetic and omics analyses of diverse and complex populations. I did my PhD in Biostatistics at the Harvard T.H. Chan School of Public Health, and graduated at 2012. Then, I continued as a postdoctoral fellow there, and later became a research scientist at the Genetic Analysis Center at the University of Washington in Seattle. At UW, I worked on genetic association analyses in the Hispanic Community Health Study/Study of Latinos, and on analysis of whole genome sequencing data from the NHLBI's Trans-Omics in Precision Medicine initiative. In late 2017 I moved to BWH and Harvard University, where I continue to develop and implement methodology for genetic and omics analyses of sleep , cognitive, cardiopulmonary, and metabolic phenotypes, with the goal of understanding the genetic basis of such phenotypes, and how environmental exposures modify the pathways from genotypes to phenotypes. I extensively collaborate with minority population studies such as the Hispanic Community Health Study/Study of Latinos, the Multi-Ethnic Study of Atherosclerosis, the Jackson Heart Study, and more.

Education and Training

• BSc, Mathematics
  The Hebrew University of Jerusalem
• PhD, Biostatistics
  Harvard University

Publications

• Recent Progress in Omics Studies of Sleep and Circadian Phenotypes.

  Wang Z, Sofer T. Curr Sleep Med Rep 2025

  PMID: 40321983

• Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.

  Petty LE, Chen HH, Frankel EG, Zhu W, Downie CG, Graff M, Lin P, Sharma P, Zhang X, Scartozzi AC, Roshani R, Landman JM, Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Sim X, Spracklen CN, Zhang W, Preuss M, Bottinger EP, Nadkarni GN, Loos RJF, Chen YI, Tan J, Ipp E, Genter P, Emery LS, Louie T, Sofer T, Stilp AM, Taylor KD, Xiang AH, Buchanan TA, Roll K, Gao C, Palmer ND, Norris JM, Wagenknecht LE, Nousome D, Varma R, McKean-Cowdin R, Guo X, Hai Y, Hsueh W, Sandow K, Parra EJ, Cruz M, Valladares-Salgado A, Wacher-Rodarte N, Rotter JI, Goodarzi MO, Rich SS, Bertoni A, Raffel LJ, Nadler JL, Kandeel FR, Duggirala R, Blangero J, Lehman DM, DeFronzo RA, Thameem F, Wang Y, Gahagan S, Blanco E, Burrows R, Huerta-Chagoya A, Florez JC, Tusie-Luna T, González-Villalpando C, Orozco L, Haiman CA, Hanis CL, Rohde R, Whitsel EA, Reiner AP, Kooperberg C, Li Y, Duan Q, Lee M, Correa-Burrows P, Fried SK, North KE, McCormick JB, Fisher-Hoch SP, Gamazon ER, Morris AP, Mercader JM, Highland HM, Below JE. Nat Commun 2025 Apr 11

  PMID: 40210677

• Association between accelerometer-measured irregular sleep duration and longitudinal changes in body mass index in older adults.

  Kianersi S, Potts KS, Wang H, Sofer T, Noordam R, Rutter MK, Redline S, Huang T. Int J Obes (Lond) 2025 Apr 06

  PMID: 40189712

• A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.

  Nagarajan P, Winkler TW, Bentley AR, Miller CL, Kraja AT, Schwander K, Lee S, Wang W, Brown MR, Morrison JL, Giri A, O'Connell JR, Bartz TM, de Las Fuentes L, Gudmundsdottir V, Guo X, Harris SE, Huang Z, Kals M, Kho M, Lefevre C, Luan J, Lyytikäinen LP, Mangino M, Milaneschi Y, Palmer ND, Rao V, Rauramaa R, Shen B, Stadler S, Sun Q, Tang J, Thériault S, van der Graaf A, van der Most PJ, Wang Y, Weiss S, Westerman KE, Yang Q, Yasuharu T, Zhao W, Zhu W, Altschul D, Ansari MAY, Anugu P, Argoty-Pantoja AD, Arzt M, Aschard H, Attia JR, Bazzanno L, Breyer MA, Brody JA, Cade BE, Chen HH, Chen YI, Chen Z, de Vries PS, Dimitrov LM, Do A, Du J, Dupont CT, Edwards TL, Evans MK, Faquih T, Felix SB, Fisher-Hoch SP, Floyd JS, Graff M, Gu C, Gu D, Hairston KG, Hanley AJ, Heid IM, Heikkinen S, Highland HM, Hood MM, Kähönen M, Karvonen-Gutierrez CA, Kawaguchi T, Kazuya S, Kelly TN, Komulainen P, Levy D, Lin HJ, Liu PY, Marques-Vidal P, McCormick JB, Mei H, Meigs JB, Menni C, Nam K, Nolte IM, Pacheco NL, Petty LE, Polikowsky HG, Province MA, Psaty BM, Raffield LM, Raitakari OT, Rich SS, Riha RL, Risch L, Risch M, Ruiz-Narvaez EA, Scott RJ, Sitlani CM, Smith JA, Sofer T, Teder-Laving M, Völker U, Vollenweider P, Wang G, Willems van Dijk K, Wilson OD, Xia R, Yao J, Young KL, Zhang R, Zhu X, Below JE, Böger CA, Conen D, Cox SR, Dörr M, Feitosa MF, Fox ER, Franceschini N, Gharib SA, Gudnason V, Harlow SD, He J, Holliday EG, Kutalik Z, Lakka TA, Lawlor DA, Lee S, Lehtimäki T, Li C, Liu CT, Mägi R, Matsuda F, Morrison AC, Penninx BW, Peyser PA, Rotter JI, Snieder H, Spector TD, Wagenknecht LE, Wareham NJ, Zonderman AB, North KE, Fornage M, Hung AM, Manning AK, Gauderman J, Chen H, Munroe PB, Rao DC, van Heemst D, Redline S, Noordam R, Wang H. Mol Psychiatry 2025 Apr 04

  PMID: 40181193

• Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos.

  Fornage M, Tarraf W, Xia R, Ordonez A, Sofer T, Márquez F, Thyagarajan B, Talavera GA, Gallo LC, DeCarli C, González HM. medRxiv 2025 Apr 04

  PMID: 40236421