Shannan Ho Sui

Biography

Shannan Ho Sui, PhD is a Principal Research Scientist in the Department of Biostatistics at the Harvard T.H. Chan School of Public Health and Director of the Harvard Chan Bioinformatics Core. She earned her PhD in Genetics from the University of British Columbia, focusing on comparative genomics and mechanisms of gene regulation, and completed postdoctoral training at Simon Fraser University in pathogen genomics. Dr. Ho Sui leads a multidisciplinary team providing bioinformatics analysis, training, and consultation for high-throughput genomics projects, with a focus on reproducible, collaborative research. Her expertise spans transcriptomics, epigenomics, and integrative multi-omics, supporting researchers in uncovering novel biological insights.

Education and Training

• B.Sc., Biochemistry
  University of British Columbia
• Ph.D, Genetics
  University of British Columbia
• , Pathogen Genomics
  Simon Fraser University

Publications

• WSTF nuclear autophagy regulates chronic but not acute inflammation.

  Wang Y, Eapen VV, Liang Y, Kournoutis A, Sherman MS, Xu Y, Onorati A, Li X, Zhou X, Corey KE, Du K, Cabral Burkard AM, Ho CK, Xie J, Zhang H, Maeso-Díaz R, Ma X, Rieprecht U, O'Brien T, Cetinbas M, Wang L, Liu J, Bretz C, Havas AP, Zhou Z, Ho Sui SJ, Saladi SV, Sadreyev RI, Adams PD, Kingston RE, Diehl AM, Alman B, Goessling W, Yue Z, Wang XF, Johansen T, Dou Z. Nature 2025 Jul 02

  PMID: 40604282

• Functional Profiling of p53 and RB Cell Cycle Regulatory Proficiency Suggests Mechanism-Driven Molecular Stratification in Endometrial Carcinoma.

  Yang Z, Mogre S, Jun H, He R, Ghosh Chaudhary S, Bhattarai UR, Ho Sui SJ, Matulonis UA, Lazo S, Shetty A, Cameron A, Nguyen QD, Hill SJ. Cancer Res Commun 2025 Apr 01

  PMID: 39932274

• Sensory input, sex and function shape hypothalamic cell type development.

  Kaplan HS, Logeman BL, Zhang K, Yawitz TA, Santiago C, Sohail N, Talay M, Seo C, Naumenko S, Ho Sui SJ, Ginty DD, Ren B, Dulac C. Nature 2025 Mar 05

  PMID: 40044853

• Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells.

  Li W, Sparks RP, Sun C, Yang Y, Pantano L, Kirchner R, Arghiani N, Weilheimer A, Toles BJ, Chen JY, Moran SP, Barrera V, Li Z, Zhou P, Brassil ML, Wrobel D, Ho Sui SJ, Aspnes G, Schuler M, Smith J, Medoff BD, Zhou C, Boustany-Kari CM, Rippmann JF, Santos DM, Doerner JF, Mullen AC. Nat Commun 2025 Mar 02

  PMID: 40025044

• Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state.

  Li J, Dang SM, Sengupta S, Schurmann P, Dost AFM, Moye AL, Trovero MF, Ahmed S, Paschini M, Bhetariya PJ, Bronson R, Ho Sui SJ, Kim CF. EMBO J 2025

  PMID: 39930268