Sean Brummel

Biography

Dr. Sean Brummel is a Senior Research Scientist in the Department of Biostatistics at the Harvard T.H. Chan School of Public Health, where he serves as a senior statistician at the Center for Biostatistics in AIDS Research (CBAR). His expertise focuses on the design, monitoring, and analysis of clinical trials studying HIV treatment during pregnancy and postpartum, as well as epidemiological research in youth affected by HIV. As a co-director of the Epidemiological and Statistical Methods Core for the Pediatric HIV/AIDS Cohort Study (PHACS) and a key member of the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT), Dr. Brummel develops statistical methodologies to address unique challenges in perinatal and maternal HIV research. His research includes estimating summary statistics when the time origin is pregnancy, analyzing longitudinally collected viral load measurements, and clarifying clinical trial design concepts. Dr. Brummel also contributes to the field through his service on data safety monitoring boards and by mentoring the next generation of biostatisticians.

Education and Training

• BS, Mathematical Statistics
  California State University, Long Beach
• MS, Statistics
  University of California, Irvine
• PhD, Statistics
  University of California, Irvine

Publications

• Bone Mineral Content, Growth, and Renal Health of Infants With Perinatal Exposure to Maternal Dolutegravir Versus Efavirenz and Tenofovir Disoproxil Fumarate Versus Tenofovir Alafenamide: The Randomized IMPAACT 2010 (VESTED) Trial.

  Mbengeranwa TG, Ziemba L, Brummel SS, Johnston B, Cassim H, Theron G, Ngqawana Z, Wabwire D, McCarthy K, Shepherd J, Lockman S, Chinula L, Stranix-Chibanda L. J Acquir Immune Defic Syndr 2025 Jun 01

  PMID: 40001275

• Selection Biases in Perinatal Research: A Comparison of Inverse Probability Weighting, Instrumental Variable and Sibling-Comparison Design.

  Dib BN, Caniglia EC, Brummel S, Shapiro R, Swanson SA. Paediatr Perinat Epidemiol 2025 Apr 25

  PMID: 40276874

• Lipid and Glucose Profiles in Pregnant Women With HIV on Tenofovir-based Antiretroviral Therapy.

  Eke AC, Brummel SS, Aliyu MH, Stranix-Chibanda L, Eleje GU, Ezebialu IU, Korutaro V, Wabwire D, Matubu A, Mbengeranwa T, Chakhtoura N, Chinula L, McCarthy K, Knowles K, Krotje C, Linton MF, Dooley KE, Sax PE, Brown T, Lockman S. Clin Infect Dis 2025 03 17

  PMID: 39219495

• Bone mineral density changes in breastfeeding women with HIV on antiretroviral therapy in Eastern and Southern Africa.

  Matovu Kiweewa F, Stranix-Chibanda L, Yende-Zuma N, Dadabhai S, Owor M, Hanley S, Nyati M, Chinula L, Pettifor JM, Brummel SS, Aizire J, Taha TE, Brown TT, Fowler MG. AIDS 2025 Jun 01

  PMID: 39918445

• Expanded Insights from a Case Study on Long-Acting Injectable Cabotegravir and Rilpivirine in Pregnancy.

  Ziemba L, Ketchum R, Brummel S. Clin Infect Dis 2024 Dec 27

  PMID: 39729033