Ronald Bosch

Biography

In collaboration with scientists at many different institutions, I work on research studies to better understand HIV reservoir biology and on clinical trials of therapies to modify the latent HIV reservoir, either directly by a treatment or through interventions to augment the immune system to better recognize and eliminate latently infected cells.

In addition, I develop and evaluate statistical methods with application to analyses of HIV persistence, assess and model HIV rebound kinetics following the withdrawal of HIV treatment which is the key clinical readout for the effect of HIV curative interventions and work to extend causal inference methods to the setting where mediators are measured subject to a lower assay limit.

Publications

• Pharmacokinetic approaches to standardize antiviral exposure in cerebrospinal fluid.

  Avedissian SN, Mu Y, McCarthy C, Bosch RJ, Spudich S, Gandhi RT, McMahon DK, Eron JJ, Mellors JW, Liu J, Podany AT, Fletcher CV. Pharmacotherapy 2025

  PMID: 40152440

• Predictors of Acute HCV Incidence in People with HIV: Insights from a Long-term Cohort Study.

  Chaillon A, Gaitan NC, Taylor LE, Wu K, Wansom T, Gianella S, Bosch RJ, Sherman KE. J Acquir Immune Defic Syndr 2025 Mar 06

  PMID: 40045466

• Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: an individual data-based meta-analysis of 24 prospective studies.

  Gunst JD, Gohil J, Li JZ, Bosch RJ, White Catherine Seamon A, Chun TW, Mothe B, Gittens K, Praiss L, De Scheerder MA, Vandekerckhove L, Escandón K, Thorkelson A, Schacker T, SenGupta D, Brander C, Papasavvas E, Montaner LJ, Martinez-Picado J, Calin R, Castagna A, Muccini C, de Jong W, Leal L, Garcia F, Gruters RA, Tipoe T, Frater J, Søgaard OS, Fidler S. Nat Commun 2025 Jan 21

  PMID: 39837813

• Fast standard error estimation for joint models of longitudinal and time-to-event data based on stochastic EM algorithms.

  Yu T, Wu L, Bosch RJ, Smith DM, Wang R. Biostatistics 2024 Dec 31

  PMID: 39523821

• Inflammatory Monocytes Increase Prior to Detectable HIV-1 Rebound Viremia.

  Farrell-Sherman A, de la Force N, Prator C, Valieris R, Azam W, Da Silva I, Deeks SG, Thanh C, Bosch R, Henrich TJ, Cohn L. bioRxiv 2024 Dec 25

  PMID: 39763863