Marouen Ben Guebila

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Biography

My research is at the interface of genomics, machine learning, and network biology. I often combine tools from these disciplines to address fundamental questions about the functioning of biological systems. I develop open-source, parallel software to leverage high-dimensional biological data to model regulatory genomics, small molecule dynamics, and metabolism in time and space.
I am currently a postdoctoral fellow at the Quackenbush lab at the Biostatistics department.

Publications

• Sex differences in gene regulation and its impact on cancer incidence.

  Lopes-Ramos CM, Burkholz R, Ben Guebila M, Fanfani V, Saha E, Shutta KH, Glass K, Quackenbush J, DeMeo DL. iScience 2026 May 15

  PMID: 42023161

• Multi-omics protein signaling networks identify sex-specific therapeutic candidates in lung adenocarcinoma.

  Chen C, Saha E, Fischer J, Ben Guebila M, Fanfani V, Shutta KH, Padi M, Glass K, DeMeo DL, Lopes-Ramos CM, Quackenbush J. Biol Sex Differ 2025 09 29

  PMID: 41024254

• Aging-associated alterations in gene regulatory networks associate with risk, prognosis and response to therapy in lung adenocarcinoma.

  Saha E, Ben Guebila M, Fanfani V, Shutta KH, DeMeo DL, Quackenbush J, Lopes-Ramos CM. NPJ Aging 2025 Jul 09

  PMID: 40634311

• Identifying Sex Differences in Lung Adenocarcinoma Using Multi-Omics Integrative Protein Signaling Networks.

  Chen C, Saha E, Fischer J, Ben Guebila M, Fanfani V, Shutta KH, Padi M, Glass K, DeMeo DL, Lopes-Ramos CM, Quackenbush J. bioRxiv 2025 Feb 07

  PMID: 39975108

• Reproducible processing of TCGA regulatory networks.

  Fanfani V, Shutta KH, Mandros P, Fischer J, Saha E, Micheletti S, Chen C, Ben Guebila M, Lopes-Ramos CM, Quackenbush J. Gigascience 2025 01 06

  PMID: 41114645