Margherita De Marzio

Biography

I am a Junior Faculty (Instructor in Medicine) at the Channing Division of Network Medicine at Brigham and Women's Hospital and Harvard Medical School. My training is in physics and I have research experience in computational biology and bioinformatics. My overarching scientific goal is to understand how cellular genomic cues coordinate the plasticity and migratory behavior of the airway epithelium. To do so, I combine a rich set of multidisciplinary approaches, including multi-omics data analysis, network science, and biophysical modeling.

Awards and Honors

• Department of Medicine Chair's Research Award, 2024
  Brigham and Women’s Hospital
• NIH K25 Mentored Quantitative Research Career Development Award, 2023 - 2028
  National Heart, Lung, and Blood Institute

Publications

• Joint clinical and molecular subtyping of COPD with variational autoencoders.

  Maiorino E, De Marzio M, Xu Z, Yun JH, Chase RP, Hersh CP, Sin DD, Weiss ST, Silverman EK, Castaldi PJ, Glass K. Nat Commun 2026 May 19

  PMID: 42151146

• Challenges and Opportunities in Single-Sample Network Modeling.

  Kuijjer M, De Marzio M, Glass K. bioRxiv 2026 Mar 02

  PMID: 41867852

• miRNA-mRNA network analysis identifies PAX5 as a potential regulator of adaptive immune response in COPD.

  Gentili M, De Marzio M, Hobbs B, Hersh CP, Ryu MH, Kuijjer ML, Cho MH, Moll M, Tern C, Castaldi P, Glass K. bioRxiv 2025 May 07

  PMID: 40654788

• The metabolic role of vitamin D in children's neurodevelopment: a network study.

  De Marzio M, Lasky-Su J, Chu SH, Prince N, Litonjua AA, Weiss ST, Kelly RS, Glass KR. Sci Rep 2024 07 23

  PMID: 39043876

• Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1.

  Kilic A, Halu A, De Marzio M, Maiorino E, Duvall MG, Bruggemann TR, Rojas Quintero JJ, Chase R, Mirzakhani H, Sungur AÖ, Koepke J, Nakano T, Peh HY, Krishnamoorthy N, Abdulnour RE, Georgopoulos K, Litonjua AA, Demay M, Renz H, Levy BD, Weiss ST. Elife 2024 Apr 03

  PMID: 38567749