Luca Pinello

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Biography

Publications

• Spatial multiomics decipher fibroblast-macrophage dynamics in systemic sclerosis.

  Li Z, Rius Rigau A, Xie W, Huang L, Ye W, Li YN, Matei AE, Bergmann C, Shao X, Zou H, Wang J, Pinello L, Distler JHW, He R, Liang M. Ann Rheum Dis 2025 May 22

  PMID: 40410053

• Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning.

  Silverstein RA, Kim N, Kroell AS, Walton RT, Delano J, Butcher RM, Pacesa M, Smith BK, Christie KA, Ha LL, Meis RJ, Clark AB, Spinner AD, Lazzarotto CR, Li Y, Matsubara A, Urbina EO, Dahl GA, Correia BE, Marks DS, Tsai SQ, Pinello L, De Ravin SS, Liu Q, Kleinstiver BP. Nature 2025 Apr 22

  PMID: 40262634

• Selective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple Myeloma.

  Rahmat M, Clement K, Alberge JB, Sklavenitis-Pistofidis R, Kodgule R, Fulco CP, Heilpern-Mallory D, Nilsson K, Dorfman D, Engreitz JM, Getz G, Pinello L, Ryan RJH, Ghobrial IM. Cancer Res 2024 Dec 16

  PMID: 39312195

• Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells.

  Zeng J, Nguyen MA, Liu P, da Silva LF, Levesque S, Lin LY, Justus DG, Petri K, Clement K, Porter SN, Verma A, Neri NR, Rosanwo T, Ciuculescu MF, Abriss D, Mintzer E, Maitland SA, Demirci S, Cha HJ, Orkin SH, Tisdale JF, Williams DA, Zhu LJ, Pruett-Miller SM, Pinello L, Joung JK, Pattanayak V, Manis JP, Armant M, Pellin D, Brendel C, Wolfe SA, Bauer DE. Cell Stem Cell 2025 Feb 06

  PMID: 39672163

• Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations.

  Lederer AR, Leonardi M, Talamanca L, Bobrovskiy DM, Herrera A, Droin C, Khven I, Carvalho HJF, Valente A, Dominguez Mantes A, Mulet Arabí P, Pinello L, Naef F, La Manno G. Nat Methods 2024

  PMID: 39482463