Kritee Mehdiratta

Biography

Publications

• PPAR? mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.

  Sarkar B, Singh J, Yadav M, Sharma P, Sharma RD, Singh S, Chandramouli A, Mehdiratta K, Kumar A, Kamat SS, Ghorpade DS, Mohanty D, Kumar D, Gokhale RS. Elife 2025 Dec 08

  PMID: 41358489

• Kupyaphores-Self-Assembling Diisocyanolipopeptide ZnII Ionophores in Mycobacterium tuberculosis ZnII/CuI/II Homeostasis and Antibacterial Effects.

  Wong TY, Sharma S, Mehdiratta K, Bhosale RS, Nimmakayala K, Wilharm RK, Chakraborty A, Orimoloye M, Liu Q, Kamat SS, Pierre VC, Gokhale RS, Aldrich CC. J Am Chem Soc 2025 Nov 05

  PMID: 41128264

• Structure-Guided Development of a Potent BioA Inhibitor Validates Biotin Synthesis Inhibition as a Therapeutic Strategy for Tuberculosis.

  Liu Q, Wallach JB, Jayasinghe YP, Sullivan MR, Proietto J, Rodriguez S, Vo S, Boshoff HIM, Jia Z, Ostrer L, Mehdiratta K, Shi R, Dartois V, Baughn AD, Rubin EJ, Ronning DR, Zimmerman MD, Schnappinger D, Aldrich CC. bioRxiv 2025 Sep 24

  PMID: 41040207

• Respiratory Quinone Switches from Menaquinone to Polyketide Quinone during the Development Cycle in Streptomyces sp. Strain MNU77.

  Mehdiratta K, Nain S, Sharma M, Singh S, Srivastava S, Dhamale BD, Mohanty D, Kamat SS, Natarajan VT, Sharma R, Gokhale RS. Microbiol Spectr 2023 02 14

  PMID: 36507669

• Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis.

  Mehdiratta K, Singh S, Sharma S, Bhosale RS, Choudhury R, Masal DP, Manocha A, Dhamale BD, Khan N, Asokachandran V, Sharma P, Ikeh M, Brown AC, Parish T, Ojha AK, Michael JS, Faruq M, Medigeshi GR, Mohanty D, Reddy DS, Natarajan VT, Kamat SS, Gokhale RS. Proc Natl Acad Sci U S A 2022 02 22

  PMID: 35193957