Jie Hu

Biography

I am an Instructor in the Center for Genomic Medicine and Department of Anaesthesia at Massachusetts General Hospital and Harvard Medical School, and the Department of Epidemiology at Harvard T.H. Chan School of Public Health. I am an epidemiologist with medical training committed to conduct research on life-course epidemiology. I have rich research experience in maternal and child health, women’s health, and environmental health.

I am interested the etiology of adverse pregnancy outcomes and their long-term impact on cardiometabolic health in women and their children. My current research utilizes large-scale, multi-omics data, under the framework of systems epidemiology, to identify novel risk factors and the underlying mechanisms of adverse pregnancy outcomes and cardiometabolic diseases in women, as well as to examine the (epi)genetic and metabolic bases of the intergenerational link in cardiometabolic disease risk. My research also extends to examining the origin and mechanisms of sex and race differences in cardiometabolic disease risk. I am also leading or participating in multiple consortium metabolomics and (epi)genetics projects in the Trans-Omics for Precision Medicine (TOPMed), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), and COnsortium of METabolomics Studies (COMETS).

Education and Training

• MD, Preventive Medicine
  Tongji Medical College, Huazhong University of Science and Technology
• PhD, Environmental Health; Epidemiology
  School of Public Health, Huazhong University of Science and Technology
• Visiting Scholar, Epidemiology
  Department of Epidemiology, Brown University School of Public Health
• Postdoctoral Research Fellow, Women's Health; Systems epidemiology; Biostatistics
  Brigham and Women’s Hospital; Mass General Hospital; Harvard T.H. Chan School of Public Health

Awards and Honors

• Winner, The Sandra A. Daugherty Award for Excellence in CVD or Hypertension Epidemiology, 2024
  American Heart Association
• Reviewers’ Choice Abstract, 2022
  American Society of Human Genetics
• Connors-BRI Research Recognition Award, 2021
  Brigham and Women's Hospital
• Early Investigator Travel Award, 2020
  American Heart Association
• Semifinalist, Charles J. Epstein Trainee Award for Excellence in Human Genetics Research, 2019
  American Society of Human Genetics
• Trudy Bush Fellowship for Cardiovascular Disease Research in Women’s Health, 2018
  American Heart Association

Publications

• Epigenetic Clock at Birth and Childhood Blood Pressure Trajectory: A Prospective Birth Cohort Study.

  Hu J, Yaskolka Meir A, Hong X, Wang G, Hu FB, Wang X, Liang L. Hypertension 2024

• Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling.

  Breithaupt L, Holsen LM, Ji C, Hu J, Petterway F, Rosa-Caldwell M, Nilsson IAK, Thomas JJ, Williams KA, Boutin R, Slattery M, Bulik CM, Arnold SE, Lawson EA, Misra M, Eddy KT. Biol Psychiatry Glob Open Sci 2024

• Differences in metabolomic profiles between Black and White women in the U.S.: Analyses from two prospective cohorts.

  McGee EE, Zeleznik OA, Balasubramanian R, Hu J, Rosner BA, Wactawski-Wende J, Clish CB, Avila-Pacheco J, Willett WC, Rexrode KM, Tamimi RM, Eliassen AH. Eur J Epidemiol 2024

• Predictive metabolites for incident myocardial infarction: a two-step meta-analysis of individual patient data from six cohorts comprising 7897 individuals from the COnsortium of METabolomics Studies.

  Nogal A, Alkis T, Lee Y, Kifer D, Hu J, Murphy RA, Huang Z, Wang-Sattler R, Kastenmüler G, Linkohr B, Barrios C, Crespo M, Gieger C, Peters A, Price J, Rexrode KM, Yu B, Menni C. Cardiovasc Res 2023 12 30

• Sex differences in the intergenerational link between maternal and neonatal whole blood DNA methylation: a genome-wide analysis in 2 birth cohorts.

  Hu J, Xu X, Li J, Jiang Y, Hong X, Rexrode KM, Wang G, Hu FB, Zhang H, Karmaus WJ, Wang X, Liang L. Clin Epigenetics 2023 03 25