Jie Hu

Biography

I am an Instructor in the Center for Genomic Medicine and Department of Anesthesiology at Massachusetts General Hospital and Harvard Medical School, and an Instructor in the Department of Epidemiology at Harvard T.H. Chan School of Public Health. I am an epidemiologist with medical training committed to conduct research on life-course epidemiology. I have rich research experience in maternal and child health, women’s health, environmental health, systems epidemiology, and biostatistics.

I am interested in understanding how genetic, metabolic, behavioral, and environmental factors contribute to disease risk across the lifespan, with an emphasizes on adverse pregnancy outcomes, cardiovascular disease, diabetes, and dementia. Under the framework of life-course epidemiology and systems epidemiology, my research projects utilize clinical, genetic, and multi-omic data from birth / pregnancy cohorts, longitudinal follow-up studies, and electronic health records-based biobanks.

My ongoing research mainly includes 3 areas: 1) Examine mechanisms underlying the development of adverse pregnancy outcomes, especially gestational diabetes mellitus and preeclampsia, and their long-term impact on cardiometabolic and cognitive health in women across the lifespan. 2) Identify risk factors and mechanisms underlying the intergenerational transmission of disease risk, especially obesity, hypertension, and cardiovascular disease 3) Understand the long-term impact of sleep and circadian disorders on cerebrovascular disease and neurodegenerative disorders, such as stroke, cognitive decline, and Alzheimer’s disease and related dementias.

Education and Training

• MD, Preventive Medicine
  Tongji Medical College, Huazhong University of Science and Technology
• PhD, Environmental Health; Epidemiology
  School of Public Health, Huazhong University of Science and Technology
• Visiting Scholar, Epidemiology
  Department of Epidemiology, Brown University School of Public Health
• Postdoctoral Research Fellow, Women's Health; Systems epidemiology; Biostatistics
  Brigham and Women’s Hospital; Mass General Hospital; Harvard T.H. Chan School of Public Health

Awards and Honors

• Winner, The Sandra A. Daugherty Award for Excellence in CVD or Hypertension Epidemiology, 2024
  American Heart Association
• Reviewers’ Choice Abstract, 2024
  American Society of Human Genetics
• Reviewers’ Choice Abstract, 2022
  American Society of Human Genetics
• Connors-BRI Research Recognition Award, 2021
  Brigham and Women's Hospital
• Early Investigator Travel Award, 2020
  American Heart Association
• Semifinalist, Charles J. Epstein Trainee Award for Excellence in Human Genetics Research, 2019
  American Society of Human Genetics
• Trudy Bush Fellowship for Cardiovascular Disease Research in Women’s Health, 2018
  American Heart Association

Publications

• Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes.

  Li J, Hu J, Yun H, Mei Z, Wang X, Luo K, Guasch-Ferré M, Han X, Truong B, Merino J, Jia C, Ruiz-Canela M, Rebholz CM, Moon EH, Alkis T, Liu G, Yao J, Zhang X, Porneala BC, Salas-Salvadó J, Wang TJ, Dupuis J, Selvin E, Guo X, Bhupathiraju SN, Brody JA, Liu Y, Wood AC, North KE, Jung SY, Liu CT, Sotoodehnia N, Liu S, Tinker LF, Eliassen AH, Manson JE, Florez JC, Gerszten RE, Clish CB, Liang L, Lemaitre RN, Tucker KL, Rich SS, Rotter JI, Martínez-González MA, Rexrode KM, Meigs JB, Boerwinkle E, Kaplan RC, Hu FB, Yu B, Qi Q. Nat Med 2026 Jan 14

  PMID: 41535386

• The timing of macronutrient and major food group intake and associations with mortality among United States adults, 1999?March 2020: a serial cross-sectional study.

  Zhang Y, Alver S, Shan Z, Mossavar-Rahmani Y, Hu J, Zhang J, St-Onge MP, Kaplan R, Xue X, Qi Q. Am J Clin Nutr 2026

  PMID: 41138914

• Metabolomic profile associated with preeclampsia and its severity: a case-control study in Colombian pregnant women.

  Colmenares-Mejia CC, Bautista-Nino PK, Quintero-Lesmes DC, Riaño C, Satizabal JM, Hu J, Gray KJ, Serrano NC. Sci Rep 2025 Aug 27

  PMID: 40866372

• Cross-omics risk scores of inflammation markers are associated with all-cause mortality: The Canadian Longitudinal Study on Aging.

  Yaskolka Meir A, Yun H, Hu J, Li J, Liu J, Bever A, Ratanatharathorn A, Song M, Eliassen AH, Chibnik L, Koenen K, Pare G, Stampfer MJ, Liang L. Am J Hum Genet 2025 Jul 03

  PMID: 40633542

• Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.

  Thedim M, Hu J, Maher M, Wiener-Kronish J, Saxena R, Vacas S. Br J Anaesth 2025 Jun 24

  PMID: 40562635