Jérémie Le Pen

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Biography

Jérémie received his formal training in Genetics and Systems Biology at École Normale Supérieure in Paris, France. He then joined Prof. Eric Miska’s laboratory at the University of Cambridge, UK, as a graduate student, focusing on small RNA biology in C. elegans. His graduate studies coincided with the discovery of the first natural virus in C. elegans, providing him with a unique opportunity to contribute to early research on viral infection and antiviral immunity in nematodes.

In 2017, Jérémie joined virologist Charles Rice’s group at Rockefeller University, NY, as a postdoctoral researcher. There, he worked on projects combining human genetics and functional genetic screens in cell cultures to better understand how the human innate immune system controls RNA viruses and live-attenuated vaccines.

Jérémie established his lab in December 2024 at the Harvard T.H. Chan School of Public Health, in the Department of Immunology and Infectious Diseases. The Le Pen Lab focuses on innate immunity to RNA viruses, aiming to uncover the diverse antiviral strategies evolved by nature across humans, nematodes, and arthropods.

Publications

• A common form of dominant human IFNAR1 deficiency impairs IFN-a and -? but not IFN-ß-dependent immunity.

  Casanova JL, Zhang Q, Al Qureshah F, Le Pen J, de Weerd NA, Moncada-Velez M, Materna M, Lin DC, Milisavljevic B, Vianna F, Bizien L, Lorenzo L, Lecuit M, Pommier JD, Keles S, Ozcelik T, Pedraza-Sanchez S, de Prost N, El Zein L, Hammoud H, Ng LFP, Halwani R, Saheb Sharif-Askari N, Lau YL, Tam AR, Singh N, Bhattad S, Berkun Y, Chantratita W, Aguilar-López R, Shahrooei M. J Exp Med 2025 Feb 03

• A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.

  Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook AW, Bauer M, Hoffmann HH, Pinharanda A, Ricardo-Lax I, Stenzel AF, Rosado-Olivieri EA, Dinnon KH, Doyle WC, Freije CA, Hong SH, Lee D, Lewy T, Luna JM, Peace A, Schmidt C, Schneider WM, Winkler R, Yip EZ, Larson C, McGinn T, Menezes MR, Ramos-Espiritu L, Banerjee P, Poirier JT, Sànchez-Rivera FJ, Cobat A, Zhang Q, Casanova JL, Carroll TS, Glickman JF, Michailidis E, Razooky B, MacDonald MR, Rice CM. PLoS Biol 2024

• SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency.

  Chan YH, Lundberg V, Le Pen J, Yuan J, Lee D, Pinci F, Volpi S, Nakajima K, Bondet V, Åkesson S, Khobrekar NV, Bodansky A, Du L, Melander T, Mariaggi AA, Seeleuthner Y, Saleh TS, Chakravarty D, Marits P, Dobbs K, Vonlanthen S, Hennings V, Thörn K, Rinchai D, Bizien L, Chaldebas M, Sobh A, Özçelik T, Keles S, AlKhater SA, Prando C, Meyts I. J Exp Med 2024 Sep 02

• The antiviral state of the cell: lessons from SARS-CoV-2.

  Le Pen J, Rice CM. Curr Opin Immunol 2024

• Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.

  Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T, Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X, Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard CL, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL. Science 2023 02 10