Jeffrey J. Fredberg

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Biography

Our laboratory seeks to discover physical laws governing the abilities of the cytoskeleton to deform, contract, and remodel. These basic mechanical processes underlie a range of higher level phenomena in health and disease including many aspects of cancer, cardiovascular disease, malaria, and morphogenesis, but our major research emphasis is the role of these processes in airway narrowing in asthma. Trainees with backgrounds in engineering sciences, cell biology, or physics of soft condensed matter learn how to work side-by-side to pose new questions, invent new nanotechnologies, apply these technologies in novel experimental investigations, and analyze resulting data in terms of evolving mechanistic understanding of the physical properties of the living cell.

Education and Training

• BSME,
  Tufts University
• PhD,
  Massachusetts Institute of Technology

Publications

• Epithelial layer fluidization by curvature-induced unjamming.

  Marzio M, Das A, Fredberg JJ, Bi D. ArXiv 2024 Nov 04

• Effects of increasing tidal volume and end-expiratory lung volume on induced bronchoconstriction in healthy humans.

  Gobbi A, Antonelli A, Dellaca R, Pellegrino GM, Pellegrino R, Fredberg JJ, Solway J, Brusasco V. Respir Res 2024 Aug 07

• Epithelial cells crowded out in asthma.

  Drazen JM, Fredberg JJ. Science 2024 Apr 05

• A life off the beaten track in biomechanics: Imperfect elasticity, cytoskeletal glassiness, and epithelial unjamming.

  Atia L, Fredberg JJ. Biophys Rev (Melville) 2023

• Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells.

  He S, Lei P, Kang W, Cheung P, Xu T, Mana M, Park CY, Wang H, Imada S, Russell JO, Wang J, Wang R, Zhou Z, Chetal K, Stas E, Mohad V, Bruun-Rasmussen P, Sadreyev RI, Hodin RA, Zhang Y, Breault DT, Camargo FD, Yilmaz ÖH, Fredberg JJ, Saeidi N. Gastroenterology 2023 06