Ana Arruda

Biography

Publications

• CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.

  Mathiowetz AJ, Meymand ES, Deol KK, Parlakgül G, Lange M, Pang SP, Roberts MA, Torres EF, Jorgens DM, Zalpuri R, Kang M, Boone C, Zhang Y, Morgens DW, Tso E, Zhou Y, Talukdar S, Levine TP, Ku G, Arruda AP, Olzmann JA. bioRxiv 2024 Jun 08

• Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets.

  Bairos JA, Njoku U, Zafar M, Akl MG, Li L, Parlakgul G, Arruda AP, Widenmaier SB. Biochim Biophys Acta Mol Cell Biol Lipids 2024

• Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity.

  Parlakgül G, Pang S, Artico LL, Min N, Cagampan E, Villa R, Goncalves RLS, Lee GY, Xu CS, Hotamisligil GS, Arruda AP. Nat Commun 2024 May 10

• Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis.

  Chang CF, Gunawan AL, Liparulo I, Zushin PH, Vitangcol K, Timblin GA, Saijo K, Wang B, Parlakgül G, Arruda AP, Stahl A. EMBO J 2024

• Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity.

  Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS. bioRxiv 2023 Feb 22