Alkes Price

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Biography

I am a professor in the Program in Genetic Epidemiology and Statistical Genetics in the Department of Epidemiology at HSPH, with a secondary appointment in the Department of Biostatistics. I am an associate member of the Program in Medical and Population Genetics at the Broad Institute, and a member of the Program in Quantitative Genomics at HSPH. I am the recipient of the 2017 Harvard Chan Outstanding Postdoctoral Mentor Award. Our research focuses on the development of statistical methods for uncovering the genetic basis of human disease, and on the population genetics underlying these methods. Areas of interest include functional components of heritability, common vs. rare variant architectures, and disease mapping in structured populations.

"Everything should be made as simple as possible, but no simpler" - Albert Einstein

Publications

• Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation.

  Akbari A, Barton AR, Gazal S, Li Z, Kariminejad M, Perry A, Zeng Y, Mittnik A, Patterson N, Mah M, Zhou X, Price AL, Lander ES, Pinhasi R, Rohland N, Mallick S, Reich D. bioRxiv 2024 Sep 15

• Fine-mapping causal tissues and genes at disease-associated loci.

  Strober BJ, Zhang MJ, Amariuta T, Rossen J, Price AL. medRxiv 2024 Jun 17

• Linking regulatory variants to target genes by integrating single-cell multiome methods and genomic distance.

  Dorans E, Jagadeesh K, Dey K, Price AL. medRxiv 2024 May 25

• Genome-wide association studies in a large Korean cohort identify novel quantitative trait loci for 36 traits and illuminates their genetic architectures.

  Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P. medRxiv 2024 May 18

• MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data.

  Rossen J, Shi H, Strober BJ, Zhang MJ, Kanai M, McCaw ZR, Liang L, Weissbrod O, Price AL. medRxiv 2024 May 13