Nika Danial

Associate Professor in the Department of Molecular Metabolism

Molecular Metabolism, Harvard T.H. Chan School of Public Health

Departments

Department of Molecular Metabolism

Other Positions

Associate Professor of Medicine

Medicine-Brigham and Women's Hospital, Harvard Medical School

Biography

Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA.

Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS. EMBO J 2023 06 01
MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.

Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD. Cell Rep 2022 10 04
Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway.

Wei P, Bott AJ, Cluntun AA, Morgan JT, Cunningham CN, Schell JC, Ouyang Y, Ficarro SB, Marto JA, Danial NN, DeBerardinis RJ, Rutter J. Sci Adv 2022 Sep 30
Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.

Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN. Cell Rep 2021 11 23
More Metabolism!

Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K. Mol Cell 2021 09 16

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