Discovery to intervention: The Healthy Life Trajectories Initiative with Stephen G. Matthews, PhD, FCAHS
Please join the Harvard Chan NIEHS Center for Environmental Health and the Department of Environmental Health for a talk by Stephen G. Matthews, PhD, FCAHS, Canada Research Chair in Early Development and Health and Professor of Physiology, Ob-Gyn and Medicine at the University of Toronto. Dr. Matthews will discuss “Discovery to intervention: The Healthy Life Trajectories Initiative.”
This event will be held in person (HSPH Bldg. 1, 1302) and via Zoom. Lunch and refreshments provided! Register here
Trainee meeting for students and postdocs immediately following the seminar, 2-3 pm, in 1306A! Come in-person to discuss research interests, career plans, and funding opportunities. RSVP here!
Abstract
It is well established that the environment during pregnancy can have a long-term impact on cardiometabolic and neurodevelopmental outcomes in offspring and increase risk of non-communicable diseases (NCDs) in later life. There is growing evidence from preclinical studies and some clinical studies that the preconception period in both females and males and the early pregnancy phase are periods of high sensitivity to environmental perturbation. The Healthy Life Trajectories Initiative (HeLTI) was developed to translate new knowledge in the area of developmental origins of health and disease (DOHaD) and improve the health of mothers, infants and children. The HeLTI consortium includes harmonized trials in Canada, China, India and South Africa designed to evaluate the impact of an integrated evidence-based intervention package, delivered through the preconception, pregnancy and postnatal period on, 1) reducing adiposity and obesity, and improving neurodevelopmental and cardiometabolic development in infants and children to 5-years of age and, 2) improving maternal health and pregnancy outcomes. All trials have completed recruitment and combine harmonized data and biospecimen collection. The HeLTI-India trial will be described in detail. Findings from the HeLTI studies will have profound implications for public health policy but will also allow determination of the mechanisms that underlie intergenerational transmission. HeLTI is funded by the Canadian Institutes for Health Research and International funding agencies (India, China and South Africa) and is partnered with WHO.
About the speaker
Stephen Matthews, PhD, FCAHS, is Canada Research Chair in Early Development and Health, Professor of Physiology, Ob-Gyn and Medicine at the University of Toronto and a Senior Scientist at the Lunenfeld-Tanenbaum Research Institute, Sinai Health. He served as Chair of the Department of Physiology (UofT; 2007-2014). He is currently Director of Research at the Alliance for Human Development, LTRI, and Director of the Ontario Birth Study. Matthews is also the Canadian lead PI of the CIHR/DBT-funded Healthy Life Trajectories (HeLTI) trial in India.
His fundamental research program is determining mechanisms by which early interventions and exposures can impact long-term neurologic and endocrine function in offspring across multiple generations. With a focus on epigenetics, his research team is determining the molecular mechanisms by which this occurs. In a parallel program, his group is investigating drug and hormone transport mechanisms in the placenta and fetal brain, with a focus on developing novel treatments to protect the developing fetal brain.
Professor Matthews is committed to translating fundamental research to improve human health. In addition to leadership of the HeLTI-India trial and the Ontario Birth Study, he co-founded the MAVAN program, which followed neurocognitive development in children following adverse early experience. He has secured over $40M in research funding, published 265 full papers and has received >300 invitations to present his work around the world. He was elected a Fellow of the Canadian Academy of Health Sciences (2019). He has served as elected President of the Society for Reproductive Investigation. In 2015, he co-founded DOHaD Canada and served as elected President (2018-23).
Speaker Information
Organizers
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