Gunes Parlakgul

Biography

Publications

• Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets.

  Bairos JA, Njoku U, Zafar M, Akl MG, Li L, Parlakgul G, Arruda AP, Widenmaier SB. Biochim Biophys Acta Mol Cell Biol Lipids 2024

• Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity.

  Parlakgül G, Pang S, Artico LL, Min N, Cagampan E, Villa R, Goncalves RLS, Lee GY, Xu CS, Hotamisligil GS, Arruda AP. Nat Commun 2024 May 10

• Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity.

  Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS. bioRxiv 2023 Feb 22

• Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease.

  Arruda AP, Parlakgül G. Cold Spring Harb Perspect Biol 2023 02 01

• Integration of ER protein quality control mechanisms defines ß cell function and ER architecture.

  Shrestha N, Torres M, Zhang J, Lu Y, Haataja L, Reinert RB, Knupp J, Chen YJ, Parlakgul G, Arruda AP, Tsai B, Arvan P, Qi L. J Clin Invest 2023 01 03