Global Health Research and Training in Non-Communicable Diseases and Perinatal Epidemiology
The Global Health Research and Training in Non-Communicable Diseases and Perinatal Epidemiology (GRAPE) Program brings together epidemiologists, clinicians, students, and investigators from Harvard and beyond to improve knowledge about the impact of interventions for preventing maternal, perinatal, and non-communicable conditions globally.
677 Huntington Avenue
Kresge, Room 500
Boston, MA 02115
Research
Pregnancy Outcomes, Maternal and Infant Study (PrOMIS) Cohort
The overarching objective of the PrOMIS cohort is to examine how maternal experiences of stress and trauma across the lifespan affect offspring health outcomes. The study also investigates potential mechanisms driving these relations (e.g. DNA methylation and maternal caregiving sensitivity).
Screening Treatment and Effective Management of Gestational Diabetes Mellitus (STEM-GDM) study
The goal of this pregnancy cohort study is to evaluate the prevalence of GDM among Peruvian women and to provide evidence to improve the local guidelines for standardized screening, diagnosis, treatment, and effective management of GDM. Glucose markers, as well as important sociodemographic, lifestyle, and mental health variables, were collected for these women in mid-pregnancy.
Teen Pregnancy Outcomes Maternal and Infant Study (TPROMIS)
Teen-PROMIS is a cohort study in Peru aimed at understanding the risk and protective risk factors for trauma and mental health among adolescent mothers in Lima, Peru aged 14-18 years old. Relevant information about sociodemographic characteristics, adverse experiences in childhood, symptoms of depression and anxiety, suicidal ideation, and resilience skills, were asked of participants through in-person interviews conducted 2-3 days post-partum by midwives trained in research methods.
Placental Abruption Genetic Epidemiology (PAGE) study
PAGE is a case-control study of placenta abruption (PA) and other adverse pregnancy outcomes like preterm birth conducted in Lima, Peru. This study was designed to study the environmental and molecular risk factors associated with adverse outcomes of pregnancy, particularly PA. Women recruited in the study were admitted for obstetrics services to antepartum wards, emergency rooms, and labor and delivery wards across participating hospitals in Lima. Sociodemographic and lifestyle factors were gathered through structured interviews at the time of delivery, as well as saliva samples to generate genetic and other multi-Omics data. Obstetric variables were retrieved from medical records.