Michael Grusby

Biography

Dr. Grusby's research interests have been on the role of a class of transcription factors called signal transducer and activator of transcription (STATs) in the differentiation and function of T helper cell subsets. Studies from his lab have shown how manipulating STAT activity can alter the function of T helper cells and therefore change the outcome of conditions such as asthma and other inflammatory diseases. In addition, Dr. Grusby has published a number of studies on the biology of the cytokine IL-21, demonstrating its critical role in the development of diabetes. Dr. Grusby served as the past Director of the PhD in Biological Sciences in Public Health (BPH) Program within the Division of Biological Sciences and as a member of the Steering Committee for the Office for Educational Programs.

Education and Training

• Ph.D,
  Northwestern University

Publications

• ZBTB20 is required for anterior pituitary development and lactotrope specification.

  Cao D, Ma X, Cai J, Luan J, Liu AJ, Yang R, Cao Y, Zhu X, Zhang H, Chen YX, Shi Y, Shi GX, Zou D, Cao X, Grusby MJ, Xie Z, Zhang WJ. Nat Commun 2016 Apr 15

• IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.

  Lajoie S, Lewkowich I, Herman NS, Sproles A, Pesce JT, Wynn TA, Grusby MJ, Hamid Q, Wills-Karp M. Clin Exp Allergy 2014

• IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.

  Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ. J Immunol 2013 Apr 15

• PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease.

  Qu Z, Fu J, Ma H, Zhou J, Jin M, Mapara MY, Grusby MJ, Xiao G. Cell Biosci 2012 Jun 25

• The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and ß cell function in mice.

  Zhang Y, Xie Z, Zhou L, Li L, Zhang H, Zhou G, Ma X, Herrera PL, Liu Z, Grusby MJ, Zhang WJ. Gastroenterology 2012