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Lester Kobzik

Department Associate

Environmental Health, Harvard T.H. Chan School of Public Health

Departments

Department of Environmental Health

Other Positions

Professor of Pathology, Emeritus

Emeritus Affiliates, Harvard Medical School

Biography

Lester's Catalyst Profile

Publications

Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice.

Shee S, Martinez-Martinez YB, Koleske B, Shaku MT, Yabaji S, Kobzik L, Kramnik I, Bishai W. Nat Commun 2026 May 07

PMID: 42098153
Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization.

Yabaji SM, Lata S, Tseng AE, Araveti PB, Lo M, Gavrish I, O'Connell AK, Gertje HP, Belkina AC, Thurman CE, Kiyokawa H, Kotton D, Tan S, Endsley JJ, Bishai WR, Crossland N, Kobzik L, Kramnik I. PLoS Pathog 2025

PMID: 41052208
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.

Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Vanvalkenburg A, Alekseyev YO, Ma Q, Dayama G, Lau NC, Johnson WE, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I. Elife 2025 Oct 02

PMID: 41037321
Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants.

Yabaji SM, Lata S, Gavrish I, Lo M, O'Connell AK, Gertje HP, Thurman CE, Crossland NA, Kobzik L, Kramnik I. STAR Protoc 2025 Sep 19

PMID: 40714561
Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice.

Shee S, Martinez-Martinez YB, Koleske B, Yabaji S, Kobzik L, Kramnik I, Bishai W. bioRxiv 2025 Jul 03

PMID: 40631209

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Biography

Publications

Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice.

Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization.

Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.

Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants.

Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice.

Unleash your potential at Harvard Chan School.