Xikun Han

Biography

Publications

• Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes.

  Li J, Hu J, Yun H, Mei Z, Wang X, Luo K, Guasch-Ferré M, Han X, Truong B, Merino J, Jia C, Ruiz-Canela M, Rebholz CM, Moon EH, Alkis T, Liu G, Yao J, Zhang X, Porneala BC, Salas-Salvadó J, Wang TJ, Dupuis J, Selvin E, Guo X, Bhupathiraju SN, Brody JA, Liu Y, Wood AC, North KE, Jung SY, Liu CT, Sotoodehnia N, Liu S, Tinker LF, Eliassen AH, Manson JE, Florez JC, Gerszten RE, Clish CB, Liang L, Lemaitre RN, Tucker KL, Rich SS, Rotter JI, Martínez-González MA, Rexrode KM, Meigs JB, Boerwinkle E, Kaplan RC, Hu FB, Yu B, Qi Q. Nat Med 2026

  PMID: 41535386

• Genome-wide association study reveals genetic architecture and evolution of human retinal pigmentation.

  Yuan J, Zhang Y, Yao Y, Li S, Liang J, Dai W, Yang J, Liu M, Zhang Q, Zhou Y, Li J, Liu H, Chen ZJ, MacGregor S, Qu J, Han X, Su J. Sci Adv 2026 Jan 02

  PMID: 41477839

• Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience.

  Liu Z, Zhang S, James BT, Galani K, Mangan RJ, Fass SB, Liang C, Wagle MM, Boix CA, Tanigawa Y, Yun S, Sung Y, Xiong X, Sun N, Hou L, Wohlwend M, Qiu M, Han X, Xiong L, Preka E, Huang L, Li WF, Ho LL, Grayson A, Mantero J, Kozlenkov A, Mathys H, Chen T, Dracheva S, Bennett DA, Tsai LH, Kellis M. Cell 2025 Sep 04

  PMID: 40752494

• Predictive Power of Polygenic Risk Scores for Intraocular Pressure or Vertical Cup-Disc Ratio.

  He W, Lee SS, Diaz Torres S, Han X, Gharahkhani P, Hunter M, Balartnasingam C, Craig JE, Hewitt AW, Mackey DA, MacGregor S. JAMA Ophthalmol 2025 Jan 01

  PMID: 39570582

• Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases.

  Li C, Chen K, Fang Q, Shi S, Nan J, He J, Yin Y, Li X, Li J, Hou L, Hu X, Kellis M, Han X, Xiong X. Cell Genom 2024 Aug 14

  PMID: 38981476